Results 241 to 250 of about 958,820 (304)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Lycopene Alleviates T-2 Toxin-Induced Testosterone Synthesis Disorder by Inhibiting ROS/p38/TORC2/CREB Axis. [PDF]

Antioxidants (Basel)
Yang X, Tang H, Chen F, Hua Z, Luo B, Li Y, Chen G, Zhang C.   +7 more
europepmc   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Reduced efficacy of an anti-toxin vaccine from senescence-driven attenuation of toxin virulence. [PDF]

JCI Insight
Du X, Tseng CW, Bjånes E, Gage H, Swan J, Tsai CM, Hajam IA, Gonzalez C, Lin B, Nizet V, Liu GY.   +10 more
europepmc   +1 more source

Effects of Selective African Spitting Cobra Venoms and Their Three-Finger Toxins on the Modulation of Platelet Function and Blood Clotting. [PDF]

Toxins (Basel)
Khatibi M, Almeida JR, Al Juwaiser A, Gilabadi S, Patel K, Vaiyapuri S.   +5 more
europepmc   +1 more source

Development of a checklist to support management of older patients with <i>Clostridioides difficile</i> infection. [PDF]

BMJ Open Qual
Rubak T, Dahl Baunwall SM, Paaske SE, Ørum M, Kongensgaard R, Kjærskov Hansen T, Gregersen M, Hvas CL.   +7 more
europepmc   +1 more source

Molecular and structural dissection of Psalmopoeus pulcher venom reveals cysteine-rich peptides that target acid-sensing ion channel 1a. [PDF]

J Biol Chem
Hu Z, Quan J, Yu J, Tang D, Feng P, Xiao B, Guo Y, Zeng Y, Zhu H, Ning Y, Liu Z, Zhao P, Xiao Z.   +12 more
europepmc   +1 more source

β3-AR/β-arrestin2 Interaction Triggers Cardiac Fibrosis Through JNK/c-Jun Pathway in Cardiac Fibroblasts. [PDF]

J Cell Mol Med
Xu Z, Zhu M, Zhou C, Duan J, Ding J, Liu J, Ying X, Wu J, Dong Y, Wang W, Qiu Z.   +10 more
europepmc   +1 more source

Gut Microbiota in Hepatocellular Carcinoma: Etiology-Specific Evidence, Mechanisms, and Translational Challenges. [PDF]

J Hepatocell Carcinoma
Guan X.
europepmc   +1 more source