Results 251 to 260 of about 209,245 (296)
The Venom Revolution in Biomedicine: Unlocking Nature's Toxin Toolkit for Therapeutic Innovation. [PDF]
Toxicol RepBose D +4 more
europepmc +1 more source
FEBS Letters, 1988 The inhibitor activity of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin was found in the membrane extract of rat liver. The inhibitor activity was found in the fractions of DEAE-Sephacel column chromatography at 50–120 mM NaCl.
Miki Hara-Yokoyama +2 more
exaly +2 more sources
Fusion protein of Δ27LFn and EFn has the potential as a novel anthrax toxin inhibitor
FEBS Letters, 2009 PA-binding domain of LF (LFn) or PA-binding domain of EF (EFn) is the anthrax protective antigen (PA) binding domain of anthrax lethal factor (LF) or edema factor (EF).
Dayong Dong, Chenguang Cai
exaly +2 more sources
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Designing a polyvalent inhibitor of anthrax toxin
Nature Biotechnology, 2001Screening peptide libraries is a proven strategy for identifying inhibitors of protein-ligand interactions. Compounds identified in these screens often bind to their targets with low affinities. When the target protein is present at a high density on the surface of cells or other biological surfaces, it is sometimes possible to increase the biological ...
M, Mourez +7 more
openaire +2 more sources
Metallopeptidase Inhibitors of Tetanus Toxin: A Combinatorial Approach
Journal of Medicinal Chemistry, 1999The bacterial protein tetanus toxin (TeNt), which belongs to the family of zinc endopeptidases, cleaves synaptobrevin, an essential synaptic protein component of the neurotransmitter exocytosis apparatus, at a single peptide bond (Gln76-Phe77). This protease activity is a particularly attractive target for designing potent and selective synthetic ...
Martin, Loïc +5 more
openaire +3 more sources
AB5 toxins: structures and inhibitor design
Current Opinion in Structural Biology, 2000High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent ligands that block binding of the toxins to their ...
E, Fan +3 more
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Diacetyl—A growth and toxin inhibitor of Aspergilli
Journal of Stored Products Research, 1985Abstract Diacetyl (2,3-butanedione) a food additive, was found to be very effective in inhibiting growth and toxin production of Aspergillus flavus, A. versicolor and A. ochraceus when grown on synthetic liquid media and on natural substrates of maize and maize flour. Total growth inhibition of A. flavus and A. versicolor was observed at 250 ppm when
Rama Devi, G, Polasa, H
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Small-Molecule Inhibitors of Ricin and Shiga Toxins
2011This review summarizes the successes and continuing challenges associated with the identification of small-molecule inhibitors of ricin and Shiga toxins, members of the RNA N-glycosidase family of toxins that irreversibly inactivate eukaryotic ribosomes through the depurination of a conserved adenosine residue within the sarcin-ricin loop (SRL) of 28S ...
Paul G, Wahome +2 more
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The Rational Design of Bacterial Toxin Inhibitors
Current Computer Aided-Drug Design, 2007Protein toxins play key roles in many infectious diseases of humans which are caused by bacteria. In some cases the toxin alone is directly responsible for the majority of the symptoms of the disease (e.g. tetanus, anthrax, diphtheria). In others the toxin is one of an arsenal of virulence factors which allow the bacterium to cause disease. Antibiotics
Graeme Clark +2 more
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