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Biofunctionalized Surfactant Mesophases as Polyvalent Inhibitors of Cholera Toxin
Bioconjugate Chemistry, 2007The cubic lyotropic mesophase composed of the ganglioside G(M1) and the synthetic surfactant phytantriol has been employed as a scaffold to prepare a polyvalent inhibitor of cholera toxin (CT). Surfactant mixtures containing up to 20% (w/w) G(M1)/phytantriol afforded a hydrated insoluble gel-like material, which retained an inverse cubic phase (Q ...
Anastasios, Polyzos +3 more
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Toxins of Animal Venoms and Inhibitors
Current Topics in Medicinal Chemistry, 2019Juliana Pavan, Zuliani +1 more
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Protein toxin inhibitors of protein synthesis.
BioFactors (Oxford, England), 1992Two classes of extremely toxic proteins kill eukaryotic cells by covalently modifying unique structural features of components that are essential for protein synthesis. Intoxication by these proteins results from the entry of a catalytic fragment into the cytoplasm. One class is typified by diphtheria toxin and Pseudomonas exotoxin A.
J P, Perentesis +2 more
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Challenges in Developing Inhibitors Against Toxins
2014Biological toxins, which are produced bymicroorganisms, plants, or animals, cause serious illnesses in humans. Some of these toxins, for example, botulinum neurotoxin, are potential agents of biological warfare and are also increasingly being used for therapeutic and cosmetic purposes.
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Unproven methods of cancer treatment coley's mixed toxins
Ca-A Cancer Journal for Clinicians, 1965Harry Grabstald
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AB toxins: structures and inhibitor design
Current Opinion in Structural Biology, 2000Christophe Verlinde +2 more
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