Results 261 to 270 of about 209,245 (296)

Some inhibitors of the effect of cholera toxin on HeLa cells

Experimental and Molecular Pathology, 1973
Abstract Evidence is presented which shows that the effect of cholera toxin on HeLa cells was inhibited by a number of agents. These included ganglioside, whole human serum, purified fractions of serum and ethacrynic acid. Theophylline potentiated the effect of the toxin.
J, Davies, D A, Tyrrell, D B, Ramsden, L N, Louis, R G, Milne   +4 more
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First round of a focused library of cholera toxin inhibitors

Carbohydrate Research, 2007
C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported.
Č. Podlipnik, I. Velter, B. La Ferla, G. Marcou, L. Belvisi, F. Nicotra, A. Bernardi   +6 more
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Biofunctionalized Surfactant Mesophases as Polyvalent Inhibitors of Cholera Toxin

Bioconjugate Chemistry, 2007
The cubic lyotropic mesophase composed of the ganglioside G(M1) and the synthetic surfactant phytantriol has been employed as a scaffold to prepare a polyvalent inhibitor of cholera toxin (CT). Surfactant mixtures containing up to 20% (w/w) G(M1)/phytantriol afforded a hydrated insoluble gel-like material, which retained an inverse cubic phase (Q ...
Anastasios, Polyzos, Malcolm R, Alderton, Raymond M, Dawson, Patrick G, Hartley   +3 more
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Functional Characterization of Peptide-Based Anthrax Toxin Inhibitors

Molecular Pharmaceutics, 2005
We have identified an optimized peptide inhibitor that can be used to develop potent anthrax toxin therapeutics. Anthrax toxin, an essential virulence factor of Bacillus anthracis, elicits many of the symptoms associated with the disease, and is responsible for death.
Kunal, Gujraty, Skanda, Sadacharan, Mia, Frost, Vincent, Poon, Ravi S, Kane, Jeremy, Mogridge   +5 more
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Inhibitors of protein synthesis block action of cholera toxin

Biochemical and Biophysical Research Communications, 1981
Abstract Prior treatment of macrophages with cycloheximide blocked the activation of adenylate cyclase by choleragen. The effect of cycloheximide was time and dose dependent and also caused by puromycin. Toxin receptors and the catalytic and regulatory components of the cyclase were still present.
J, Hagmann, P H, Fishman
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Challenges in Developing Inhibitors Against Toxins

2014
Biological toxins, which are produced bymicroorganisms, plants, or animals, cause serious illnesses in humans. Some of these toxins, for example, botulinum neurotoxin, are potential agents of biological warfare and are also increasingly being used for therapeutic and cosmetic purposes.
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Protein toxin inhibitors of protein synthesis.

BioFactors (Oxford, England), 1992
Two classes of extremely toxic proteins kill eukaryotic cells by covalently modifying unique structural features of components that are essential for protein synthesis. Intoxication by these proteins results from the entry of a catalytic fragment into the cytoplasm. One class is typified by diphtheria toxin and Pseudomonas exotoxin A.
J P, Perentesis, S P, Miller, J W, Bodley   +2 more
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Toxins of Animal Venoms and Inhibitors

Current Topics in Medicinal Chemistry, 2019
Juliana Pavan, Zuliani, Andreimar Martins, Soares   +1 more
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Fungal Enzyme Inhibitors as Pharmaceuticals, Toxins and Scourge of PCR

Current Enzyme Inhibition, 2008
To indicate the importance of fungal enzyme inhibitors (FEI) it is only required to mention penicillin. However, many other natural products from fungi have been described. Combinatorial chemistry (CC) is not providing the medicines that were predicted and it is time to return to natural products (NP). The inhibitions of enzymes by FEI run the gamut of
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Design andin silicoscreening of inhibitors of the cholera toxin

Expert Opinion on Drug Discovery, 2009
Cholera toxin (CT) is the causative agent for cholera, which is responsible for the death of millions of people. The holotoxin structure of CT in conjunction with its mechanism of action reveals four potential target areas to design CT therapeutic agents: i) the inhibition of adenylate cyclase; ii) the blockage of the active site of the enzyme located ...
openaire   +2 more sources