Results 71 to 80 of about 264,116 (269)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Toxin–Host Interaction of Clostridium Toxins

Toxins
Clostridial toxins, involved in a wide range of serious diseases, affect humans and animals [...]
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An International Proficiency Test to Detect, Identify and Quantify Ricin in Complex Matrices

Toxins, 2015
While natural intoxications with seeds of Ricinus communis (R. communis) have long been known, the toxic protein ricin contained in the seeds is of major concern since it attracts attention of those intending criminal, terroristic and military misuse. In
Sylvia Worbs, Martin Skiba, Jennifer Bender, Reinhard Zeleny, Heinz Schimmel, Werner Luginbühl, Brigitte G. Dorner   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Clinical and immunological comparison of COVID-19 disease between critical and non-critical courses: a systematic review and meta-analysis

Frontiers in Immunology
IntroductionAcute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which appeared in 2019, has been classified as critical and non-critical according to clinical signs and symptoms. Critical patients require mechanical ventilation and intensive care unit
Mojtaba Hedayati-Ch, Mojtaba Hedayati-Ch, Hadi Sedigh Ebrahim-Saraie, Arash Bakhshi   +3 more
doaj   +1 more source

Dynamics of the cyanobacterial water bloom with focus to Microcystis and its relationship with environmental factors in Brno reservoir

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
Our paper brings new information about long-term changes of the phytoplankton communities in the Brno reservoir with the focus on the Microcystis abundance using the semi-monthly monitoring data covering the period 2006–2012.
Lucie Straková, Radovan Kopp, Eliška Maršálková, Blahoslav Maršálek   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Preliminary Investigation of GC–MS Profiling and Antibacterial Activities of Different Solvent Extracts From Litchi chinensis Sonn. Seed

Scientifica
Traditionally different parts of Litchi chinensis Sonn. (Family: Sapindaceae) have been used medicinally to treat a variety of diseases, including stomach ulcers, flatulence, obesity, cough, diabetes, and hernia-like situations.
Samia Sharmin, Ali Ahsan Muzahid, Md. Mohibul Islam, Mst. Sarmina Yeasmin, Amit Kumar Dey, Md. Jasim Uddin, G. M. Masud Rana, Jaytirmoy Barmon, Safaet Alam, Md. Nurul Huda Bhuiyan, Nazim Uddin Ahmed   +10 more
doaj   +1 more source