Results 71 to 80 of about 100,749 (257)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Genotoxic Activity of Cerastes cerastes Viper Venom Using Alkaline Single-Cell Gel Electrophoresis

Biology
In Morocco, Cerastes cerastes snake is responsible for numerous cases of human envenomation, leading to both local and systemic pathophysiological disturbances.
Zineb Ouhemmou, Nouhaila Benbaak, Zahraa Laouija, Soukaina Behlaouane, Nouhaila El Fenni, Mouad Mkamel, Mounia Cherki, Mehdi Karkouri, Fatima Chgoury   +8 more
doaj   +1 more source

From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery

Frontiers in Pharmacology, 2020
Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic ...
Karla de Castro Figueiredo Bordon, Camila Takeno Cologna, Elisa Corrêa Fornari-Baldo, Ernesto Lopes Pinheiro-Júnior, Felipe Augusto Cerni, Fernanda Gobbi Amorim, Fernando Antonio Pino Anjolette, Francielle Almeida Cordeiro, Gisele Adriano Wiezel, Iara Aimê Cardoso, Isabela Gobbo Ferreira, Isadora Sousa de Oliveira, Johara Boldrini-França, Manuela Berto Pucca, Mateus Amaral Baldo, Eliane Candiani Arantes   +15 more
doaj   +1 more source

The ADP-Ribosylating Toxins of Salmonella

, 2019
A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens.
Martin Wiedmann, Rachel A. Cheng
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Health and Environmental Impacts of Cyanobacteria and Cyanotoxins from Freshwater to Seawater

Toxins
Cyanobacterial harmful algal blooms (cyanoHABs) are a natural phenomenon produced mainly by the interaction between natural and anthropogenic events. CyanoHABs are characterized by the production of cyanotoxins that can have harmful effects on different ...
Tamara Villalobos, Benjamín Suárez-Isla, Carlos Garcia   +2 more
doaj   +1 more source

The Cytocidal Spectrum of Bacillus thuringiensis Toxins: From Insects to Human Cancer Cells

, 2020
Bacillus thuringiensis (Bt) is a ubiquitous bacterium in soils, insect cadavers, phylloplane, water, and stored grain, that produces several proteins, each one toxic to different biological targets such as insects, nematodes, mites, protozoa, and ...
Gretel Mendoza-Almanza, Jorge Olmos-Soto, Marisa Mercado-Reyes, Marisa Hernández-Barrales, Edgar L. Esparza-Ibarra, Jorge L. Ayala-Luján, Susana Godina-González   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

True or false coral snake: is it worth the risk? A Micrurus corallinus case report

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Bites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus, which together represent almost 80% of accidents.
Marcelo Abrahão Strauch, Guilherme Jones Souza, Jordana Nahar Pereira, Tyelli dos Santos Ramos, Marcelo Oliveira Cesar, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Fernando Chagas Patrão-Neto, Paulo A. Melo   +8 more
doaj   +1 more source