Results 141 to 150 of about 141,956 (266)

Integrative In Silico Identification of TP53-Associated Drug Repurposing Candidates in Lung Adenocarcinoma. [PDF]

Pharmaceuticals (Basel)
Tuncal A, Kalkan R.
europepmc   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Genome-Wide CRISPR/Cas9 Screening Identifies Modulators of THZ1 Response in Acute Myeloid Leukemia. [PDF]

Biomedicines
Ding W, Yun X, Liu Y, Liu H.
europepmc   +1 more source

Cytoreductive Surgery in Patients With Metastatic Succinate Dehydrogenase‐Deficient Gastrointestinal Stromal Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Succinate dehydrogenase‐deficient (SDH‐deficient) gastrointestinal stromal tumors (GIST) are characterized by variable disease biology with poor responses to traditional tyrosine kinase inhibitors. The role of surgical intervention has been highly debated.
Katherine Y. Chen, Mark Antkowiak, Ashwyn K. Sharma, Robert Mallory, Adam M. Burgoyne, Paul T. Fanta, Jason K. Sicklick   +6 more
wiley   +1 more source

RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish. [PDF]

PLoS Genet
Lubash BT, Gutierrez R, Hansen NA, Fink K, Hopkins CA, Sands LB, Nelson JC, Watt KEN.   +7 more
europepmc   +1 more source

TP53

Oncology Times, 2019
openaire   +2 more sources

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

Molecular Characterization of <i>TP53</i> Variants in Exons 4-8 and p53 Immunoexpression in a Mexican Colorectal Cancer Cohort. [PDF]

Cancers (Basel)
García-Ayala FD, Ayala-Madrigal ML, Peregrina-Sandoval J, Moreno-Ortiz JM, González-Mercado A, Franco-Topete RA, Valenzuela-Pérez JA, Macías-Gómez NM, Flores-López BA, Gutiérrez-Angulo M.   +9 more
europepmc   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source

A novel prognostic biomarker combining <i>TP53</i> loss-of-function and amplification of different combinations of nine genes in lung squamous cell carcinoma treated with chemotherapy. [PDF]

Oncol Lett
Li Y, Hou T, Liu H, Du H, Qiu L, Zhang Y, Zhang G, Tang Y.   +7 more
europepmc   +1 more source