Results 141 to 150 of about 240,433 (353)

Supplementary Data from Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type <i>TP53</i> Solid Tumors and Acute Leukemia

, 2023
Eytan M. Stein, Daniel J. DeAngelo, Jörg Chromik, Manik Chatterjee, Sebastian Bauer, Chia‐Chi Lin, Cristina Suárez, Filip De Vos, Neeltje Steeghs, Philippe A. Cassier, David Tai, Jean‐Jacques Kiladjian, Noboru Yamamoto, Rogier Mous, Jordi Esteve, Hironobu Minami, Stéphane Ferretti, Nelson Guerreiro, Christophe Meille, Rajkumar Radhakrishnan, Bernard Pereira, Luisa Mariconti, Ensar Halilovic, Claire Fabre, Cecilia Carpio   +24 more
openalex   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Supplementary Data from Coaltered <i>Ras/B-raf</i> and <i>TP53</i> Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer

, 2023
Jashodeep Datta, J. Joshua Smith, Walid K. Chatila, John C. McAuliffe, Cyriac Kandoth, Efsevia Vakiani, Timothy L. Frankel, Karuna Ganesh, Isaac Wasserman, Marla Lipsyc-Sharf, José G. Guillem, Garrett M. Nash, Philip B. Paty, Martin R. Weiser, Leonard B. Saltz, Michael F. Berger, William R. Jarnagin, Vinod Balachandran, T. Peter Kingham, Nancy E. Kemeny, Andrea Cercek, Julio García‐Aguilar, Barry S. Taylor, Agnès Viale, Rona Yaeger, David B. Solit, Nikolaus Schultz, Michael I. D’Angelica   +27 more
openalex   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

A substantial proportion of apparently heterozygousTP53pathogenic variants detected with a next‐generation sequencing hereditary pan‐cancer panel are acquired somatically [PDF]

, 2019
Bradford Coffee, Hannah C. Cox, Ryan Bernhisel, Susan Manley, Karla R. Bowles, Benjamin B. Roa, Debora Mancini‐DiNardo   +6 more
openalex   +1 more source

Supplemental Figure Legend from TP53 Silencing Bypasses Growth Arrest of BRAF^V600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis

, 2023
Anny Shai, David Dankort, Joseph Juan, Shon Green, Martin McMahon   +4 more
openalex   +1 more source

Real‐World Treatment and Outcomes in Resectable Early‐Stage Non‐Small Cell Cancer: THASSOS‐INTL Australia Cohort

AGING MEDICINE, EarlyView.
Australia cohort of THASSOS‐INTL; non‐interventional, multicenter, retrospective study provides insights into treatment patterns and associated survival outcomes in patients with resectable stage I‐III NSCLC in the pre‐immunotherapy era. Neoadjuvant and adjuvant therapy was reported in < 10% and < 40% patients, respectively.
Pei Ding, Kevin Jasas, Victoria Bray, Abhijit Pal, Rebecca Moor   +4 more
wiley   +1 more source

Using real-time qPCR to evaluate RNAi-mediated gene silencing [PDF]

, 2009
De Clercq, S, De Paepe, Anne, Marine, J C, Mestdagh, Pieter, Pattyn, Filip, Speleman, Franki, Van Maerken, Tom, Vandesompele, Jo, Yigit, Nurten   +8 more
core   +2 more sources

Systematic Inspection of the Clinical Relevance of TP53 Missense Mutations in Gastric Cancer [PDF]

, 2018
Seong Ryeol Moon, Curt Balch, Sungjin Park, Jinhyuk Lee, Ji‐Yong Sung, Seungyoon Nam   +5 more
openalex   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source