Results 11 to 20 of about 1,293 (78)

GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA. [PDF]

Cancer Med
GRB2 as a flexible protein and an RBP that is involved in post‐transcriptional regulation in eukaryotes, influencing all stages of mRNA synthesis, modification, splicing, and stabilization. ABSTRACT Purpose The flexible protein GRB2 interacts with HER1–4 on the cell surface and regulates the development of tumor cells; meanwhile, it is also an RBP that
Liu W, Huang Y, Qiao L, Chong L, Xia L, Abudurehaman A, Li H.   +6 more
europepmc   +2 more sources

Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia

Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023
Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi   +3 more
wiley   +1 more source

TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling [PDF]

Carcinogenesis, 2017
Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma (GBM). To decipher the underlying mechanisms of heterogeneity, patient-derived adult GBM cells were separately isolated from margins of T1 gadolinium enhancing tumor lesions (PNCs) and T1 gadolinium enhancing core lesions (ECs). Single clone culture was conducted in
Zhou, Qiang, Li, Jun-Jie, Wang, Hai, Li, Hong, Lei, Bing-Xi, Chen, Lei, Xiang, Wei, Liu, Ya-Wei, Annie, Huang, Qi, Song-Tao, Lu, Yun-Tao   +10 more
openaire   +2 more sources

Identification of diagnostic markers of pancreatic ductal adenocarcinoma using transcriptomic tumour and blood sample data

Clinical and Translational Discovery, Volume 3, Issue 5, October 2023., 2023
In this study, we pool publicly available gene expression data from clinical samples (tissue biopsies and blood samples) and derive and validate a signature of consistently deregulated genes across pancreatic ductal adenocarcinoma (PDAC) samples.
Aristeidis Sionakidis, Panagiotis Nikolaos Lalagkas, Andigoni Malousi, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis

Brain Pathology, Volume 33, Issue 5, September 2023., 2023
A combined stereological and proteomic analysis revealed amygdala volume reduction linked to synaptic dysfunction in Alzheimer''s disease samples. The pathological markers gradient suggested the relevance of connections in the distribution of the pathology among different brain regions.
Melania Gonzalez‐Rodriguez, Sandra Villar‐Conde, Veronica Astillero‐Lopez, Patricia Villanueva‐Anguita, Isabel Ubeda‐Banon, Alicia Flores‐Cuadrado, Alino Martinez‐Marcos, Daniel Saiz‐Sanchez   +7 more
wiley   +1 more source

Clathrin light chain A‐enriched small extracellular vesicles remodel microvascular niche to induce hepatocellular carcinoma metastasis

Journal of Extracellular Vesicles, Volume 12, Issue 8, August 2023., 2023
Abstract Small extracellular vesicles (sEVs) play a key role in exchanging cargoes between cells in tumour microenvironment. This study aimed to elucidate the functions and mechanisms of hepatocellular carcinoma (HCC) derived sEV‐clathrin light chain A (CLTA) in remodelling microvascular niche.
Yi Xu, Yue Yao, Liang Yu, Xiaoxin Zhang, Xiaowen Mao, Sze Keong Tey, Samuel Wan Ki Wong, Cherlie Lot Sum Yeung, Tung Him Ng, Melody YM Wong, Chi‐Ming Che, Terence Kin Wah Lee, Yi Gao, Yunfu Cui, Judy Wai Ping Yam   +14 more
wiley   +1 more source

Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK

Cancer Medicine, Volume 12, Issue 1, Page 488-499, January 2023., 2023
TPD52 forms a stable complex with AMPKα and negatively regulates AMPKα kinase activity. TPD52 modulates cell metabolism through regulating AMPK. Abstract Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases.
Yali Chen, Changmin Peng, Wei Tan, Jia Yu, Jacqueline Zayas, Yihan Peng, Zhenkun Lou, Huadong Pei, Liewei Wang   +8 more
wiley   +1 more source

Interacting partners of Golgi‐localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP‐Trap pull down

FEBS Letters, Volume 596, Issue 18, Page 2382-2399, September 2022., 2022
Identifying interactomes of membrane‐associated small G proteins is challenging. Here, we applied three proteomic approaches to identify the interactive neighbourhood of constitutively active Arl5b, a small G protein of the trans‐Golgi network (TGN). 50% of the hits were TGN/Golgi‐localised small G proteins, indicating an organised complex of small G ...
Fiona J. Houghton, Christian Makhoul, Ellie Hyun‐Jung Cho, Nicholas A. Williamson, Paul A. Gleeson   +4 more
wiley   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022
Abstract Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day 1 = vaginal plug), blastocyst attachment is completed within 24 h, accompanied by dynamic interactions between the uterine luminal epithelium and the blastocysts.
Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Chihiro Ishizawa, Rei IIda, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga   +10 more
wiley   +1 more source