Results 21 to 30 of about 1,293 (78)

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays

BMC Genomics, 2008
Background Tumor-predominant splice isoforms were identified during comparative in silico sequence analysis of EST clones, suggesting that global aberrant alternative pre-mRNA splicing may be an epigenetic phenomenon in cancer. We used an exon expression
Nixon Tamara J, Neubauer Valerie L, Bachinski Linda L, Tsavachidis Spiridon, Baggerly Keith A, Cheung Hannah C, Aldape Kenneth D, Cote Gilbert J, Krahe Ralf   +8 more
doaj   +1 more source

MicroRNA-217 inhibits cell proliferation, invasion and migration by targeting Tpd52l2 in human pancreatic adenocarcinoma

Oncology Reports, 2017
MicroRNAs (miRNAs) play important roles in the regulation of various tumor biological processes including proliferation and apoptosis. miR-217 has been implicated in many types of cancer, whereas its expression and potential biological function in human pancreatic adenocarcinoma (HPAC) remain unclear.
Qiuyang, Chen, Peng, Wang, Yue, Fu, Xinchun, Liu, Wenbin, Xu, Jishu, Wei, Wentao, Gao, Kuirong, Jiang, Junli, Wu, Yi, Miao   +9 more
openaire   +3 more sources

Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration.

PLoS ONE, 2013
PML protein plays important roles in regulating cellular homeostasis. It forms PML nuclear bodies (PML-NBs) that act like nuclear relay stations and participate in many cellular functions.
Mei Kuen Tang, Yong Jia Liang, John Yeuk Hon Chan, Sing Wan Wong, Elve Chen, Yao Yao, Jingyi Gan, Lihai Xiao, Hin Cheung Leung, Hsiang Fu Kung, Hua Wang, Kenneth Ka Ho Lee   +11 more
doaj   +1 more source

Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis‐Related Glycoprotein in Lung Cancer

Journal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
Abstract Lung cancer is the most prevalent malignancy worldwide, with the majority of fatalities attributed to metastasis. Recent studies have demonstrated the pivotal role of extracellular vesicles (EVs) and glycoproteins in tumor progression. In this study, we compared the glycoproteome of EVs from 95C (low metastatic) and 95D (high metastatic) lung ...
Lu Zhang, Yan Wu, Suntao Li, Miao Guo, Jiaqi Zhao, Chengxi Cao, Yan Zhang, Hua Xiao   +7 more
wiley   +1 more source

New insights into the mechanisms of childhood food allergies

Pediatric Allergy and Immunology, Volume 36, Issue 4, April 2025.
Abstract IgE‐mediated food allergies are common and can be life‐threatening, especially for children. With increasingly rapid advances in immunological technologies, including the ability to profile highly complex immune features from small sample volumes, our understanding of the immune mechanisms that underpin the development of food allergies ...
Liam Gubbels, Richard Saffery, Melanie R. Neeland   +2 more
wiley   +1 more source

Time‐Lapse Acquisition of Both Freely Secreted Proteome and Exosome Encapsulated Proteome in Live Organoids’ Microenvironment

Advanced Science, Volume 12, Issue 2, January 13, 2025.
Proteomic communications in neighboring microenvironments during early organ development is a dynamic process continuously reshaping hESCs developmental fate. Such dynamic proteomic alteration consists of freely secreted proteome and exosome‐encapsulated proteome.
Haoni Yan, Aynur Abdulla, Aiting Wang, Shuyu Ding, Manlin Zhang, Yizhi Zhang, Tsz Yui Zhuang, Leqi Wu, Yan Wang, Rongrong Ren, Lai Jiang, Xianting Ding   +11 more
wiley   +1 more source

The selenoenzyme type I iodothyronine deiodinase: a new tumor suppressor in ovarian cancer

Molecular Oncology, Volume 18, Issue 9, Page 2298-2313, September 2024.
The selenoenzyme deiodinase type 1 (DIO1) has anti‐tumor actions in high‐grade serous ovarian cancer. Reduced levels of DIO1 in HGSOC cells and human tissues facilitate proliferation and may promote tumorigenesis in this aggressive disease. The selenoenzyme type I iodothyronine deiodinase (DIO1) catalyzes removal of iodine atoms from thyroid hormones ...
Adi Alfandari, Dotan Moskovich, Avivit Weisz, Aviva Katzav, Debora Kidron, Mario Beiner, Dana Josephy, Aula Asali, Yael Hants, Yael Yagur, Omer Weitzner, Martin Ellis, Gilad Itchaki, Osnat Ashur‐Fabian   +13 more
wiley   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

HB‐EGF‐loaded nanovesicles enhance trophectodermal spheroid attachment and invasion

PROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial cells and subsequently invade the underlying matrix are critical stages of embryo implantation during successful pregnancy establishment. Extracellular vesicles (EVs) have been implicated in embryo‐maternal crosstalk, capable of reprogramming ...
Qi Hui Poh, Alin Rai, Jonathon Cross, David W. Greening   +3 more
wiley   +1 more source

Analysis of 206 whole‐genome resequencing reveals selection signatures associated with breed‐specific traits in Hu sheep

Evolutionary Applications, Volume 17, Issue 6, June 2024.
Abstract As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection. Identifying selection signatures in Hu sheep can provide a straightforward insight into the mechanism
Fuping Zhao, Rui Xie, Lingzhao Fang, Ruidong Xiang, Zehu Yuan, Yang Liu, Lixian Wang   +6 more
wiley   +1 more source