Results 71 to 80 of about 125,091 (256)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Compressive load bearing and bone architecture of lumbar vertebrae in terms of sex and aging [PDF]

, 2004
Relation between vertebral compressive strength and trabecular architecture is presented in terms of aging and sex. Complex in vitro medical-engineering analysis of cadaver human lumbar L1 and L2 vertebrae was executed: densitometry, CT, MRI, mechanical ...
Fornet, B., Kurutzné Kovács, Márta, Gálos, M.   +2 more
core   +1 more source

Model-Independent 3D Descriptors of Vertebral Cancellous Bone Architecture

Journal of Osteoporosis, 2010
High-resolution micro computed tomography has enabled measurement of bone architecture derived from 3D representations of cancellous bone. Twenty-eight vertebral bodies were obtained from four embalmed male cadavers.
Ian H. Parkinson, Danielle Forbes, Peter Sutton-Smith, Nicola L. Fazzalari   +3 more
doaj   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Cortical unlike trabecular bone loss is not associated with vascular calcification progression in CKD patients

BMC Nephrology, 2020
Background Vascular calcification progression has been associated with the loss of trabecular bone in chronic kidney disease (CKD) patients. There are few data evaluating the relationship between cortical bone loss and vascular calcification in this ...
Larissa R. Costa, Aluizio B. Carvalho, Amandha L. Bittencourt, Carlos E. Rochitte, Maria Eugênia F. Canziani   +4 more
doaj   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source

Effect of trabecular bone loss on cortical strain rate during impact in an in vitro model of avian femur

BioMedical Engineering OnLine, 2006
Background Osteoporotic hip fractures occur due to loss of cortical and trabecular bone mass and consequent degradation in whole bone strength. The direct cause of most fractures is a fall, and hence, characterizing the mechanical behavior of a whole ...
Gefen Amit, Reich Tal
doaj   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

, 2019
Porous metal scaffolds play an important role in the orthopedic field, due to their wide applications in prostheses implantation. Some previous studies showed that the scaffolds with trabecular bone structure reconstructed via computed tomography had ...
Deqiao Xie (14722661), Youwen Yang (8354832), Qing Jiang (197843), Lan Li (73597), Ning Mao (564037), Chang Wang (4464778), Zongjun Tian (14722664), Huixin Liang (5344523), Lida Shen (400305)   +8 more
core   +1 more source

A Specimen-Based Comparative MicroCT–FEA Analysis of Vertebral Trabecular Bone Microarchitecture and Mechanical Response in Two South American Cervids: The Patagonian Huemul (Hippocamelus bisulcus) and the Southern Pudu (Pudu puda)

Biology
The Patagonian huemul (Hippocamelus bisulcus) and the Southern pudu (Pudu puda) are native South American cervids that differ in body size, ecology, and conservation status.
Danae Tapia, Álvaro González, Fernando Vidal, Paulo Salinas   +3 more
doaj   +1 more source