Results 11 to 20 of about 14,535 (168)
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome. [PDF]
Adv Sci (Weinh)By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Chen S +11 more
europepmc +2 more sources
Biomaterials and Biosystems, 2021 Glaucoma is the second leading cause of irreversible blindness worldwide. Glaucoma is a progressive optic neuropathy in which permanent loss of peripheral vision results from neurodegeneration in the optic nerve head.
Devon J. Crouch +4 more
doaj +1 more source
Journal of Agromedicine and Medical Sciences (AMS), 2017 In primary open angle glaucoma, decrease of hyaluronic acid level is related to extracellular matrix deposition of trabecular meshwork. Extracellular matrix deposition will increase humor aqueous outflow resistance which in turn increase the intraocular ...
Cicih Komariah +2 more
doaj +1 more source
Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study. [PDF]
PLoS ONE, 2016 Myopia subjects usually have long axial lengths and are predisposed to deep anterior chamber depths and open angles. Jiangning eye study is a randomized, population based study in Shanghai to determine whether myopia has an effect on the prevalence of ...
Xiaohong Liu +9 more
doaj +1 more source
Implantation of trabecular micro-bypass stent using a novel “landing strip” technique [PDF]
International Journal of Ophthalmology, 2017 AIM: To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent (iStent) implantation in patients who underwent phacoemulsification.
Cindy X. Zheng +5 more
doaj +1 more source
Trabecular meshwork gene expression after selective laser trabeculoplasty.
PLoS ONE, 2011 BackgroundTrabecular meshwork and Schlemm's canal are the tissues appointed to modulate the aqueous humour outflow from the anterior chamber. The impairment of their functions drives to an intraocular pressure increase.
Alberto Izzotti +4 more
doaj +1 more source
Morphological changes in the iridocorneal angle and their relationship with intraocular pressure after infantile cataract surgery [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate morphological changes in the iridocorneal angle after pediatric cataract surgery. METHODS: Children who underwent primary infantile cataract surgery were included and 64 eyes from 41 children, including 18 with unilateral cataracts (18 ...
Dan-Dan Wang +5 more
doaj +1 more source
RNA interference as a gene silencing therapy for mutant
Diagnostic Pathology, 2009 Background Primary open-angle glaucoma (POAG) is the most common form of glaucoma which is an irreversible blind leading disease and lacks effective remedies.
Sun Xinghuai +3 more
doaj +1 more source
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
Frontiers in Cell and Developmental Biology, 2022 Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk +4 more
doaj +1 more source
Indian Journal of Ophthalmology, 2012 Purpose: To study ultrastructural changes of the trabecular meshwork in acute and chronic primary angle closure glaucoma (PACG) and primary open angle glaucoma (POAG) eyes by scanning electron microscopy.
Ramanjit Sihota +4 more
doaj +1 more source