Results 11 to 20 of about 23,257 (267)
Oxidative damage and autophagy in the human trabecular meshwork as related with ageing.
PLoS ONE, 2014 Autophagy is an intracellular lysosomal degradation process induced under stress conditions. Autophagy also plays a major role in ocular patho-physiology. Molecular aging does occur in the trabecular meshwork, the main regulator of aqueous humor outflow,
Alessandra Pulliero +5 more
doaj +2 more sources
Human Trabecular Meshwork Progenitors [PDF]
International Journal of Medical Sciences, 2019 Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial ...
Zhu, Qin +5 more
openaire +2 more sources
Pharmaceutics, 2021 In glaucoma therapy, nanoparticles (NPs) are a favorable tool for delivering drugs to the outflow tissues of the anterior chamber of the eye where disease development and progression take place.
Tobias Sonntag +5 more
doaj +1 more source
Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis. [PDF]
PLoS ONE, 2015 A traditional Chinese medicine, Tetramethylpyrazine (TMP), has been prescribed as a complementary treatment for glaucoma to improve patient prognosis. However, the pharmacological mechanism of action of TMP is poorly understood.
Na Yu +12 more
doaj +1 more source
Trabecular meshwork stiffness in glaucoma [PDF]
Experimental Eye Research, 2017 Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain data suggest an association between elevated intraocular pressure (IOP) and increased TM stiffness; however, the underlying link between TM stiffness and IOP remains ...
Ke, Wang +3 more
openaire +2 more sources
Biomaterials and Biosystems, 2021 Glaucoma is the second leading cause of irreversible blindness worldwide. Glaucoma is a progressive optic neuropathy in which permanent loss of peripheral vision results from neurodegeneration in the optic nerve head.
Devon J. Crouch +4 more
doaj +1 more source
Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review. [PDF]
, 2016 Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire
Huang, Alex S +2 more
core +1 more source
Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. [PDF]
, 2017 Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the ...
Christian, Brian J +11 more
core +2 more sources
A comparative study of the elastic fibre system within the mouse and human cornea [PDF]
, 2018 The cornea relies on its organised extracellular matrix for maintaining transparency and biomechanical strength. Studies have identified an elastic fibre system within the human posterior cornea, thought to allow for slight deformations in response to ...
Feneck, Eleanor M. +3 more
core +2 more sources
Rare diseases leading to childhood Glaucoma. epidemiology, pathophysiogenesis, and management [PDF]
, 2015 Noteworthy heterogeneity exists in the rare diseases associated with childhood glaucoma. Primary congenital glaucoma is mostly sporadic; however, 10% to 40% of cases are familial. CYP1B1 gene mutations seem to account for 87% of familial cases and 27% of
Abdolrahimzadeh, Solmaz +5 more
core +3 more sources