Results 21 to 30 of about 16,541 (253)
Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis. [PDF]
PLoS ONE, 2015 A traditional Chinese medicine, Tetramethylpyrazine (TMP), has been prescribed as a complementary treatment for glaucoma to improve patient prognosis. However, the pharmacological mechanism of action of TMP is poorly understood.
Na Yu +12 more
doaj +1 more source
The Role of Integrins in the Trabecular Meshwork [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2013 Abstract Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). However, integrins are not just adhesion receptors. They can act as “bidirectional signal transducers” that coordinate a large number of cellular activities in response to the extracellular environment and ...
Debjani, Gagen +3 more
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Lysyl Oxidases in the Trabecular Meshwork [PDF]
Journal of Glaucoma, 2014 The mechanical properties of the extracellular matrix (ECM) play an important role in maintaining cellular function and overall tissue homeostasis. Emerging evidence suggests that biomechanical modifications of the ECM may be initiators and/or drivers of disease, exemplified by increased tissue stiffness.
Robert J, Wordinger, Abbot F, Clark
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Human Trabecular Meshwork Progenitors [PDF]
International Journal of Medical Sciences, 2019 Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial ...
Zhu, Qin +5 more
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Role of MicroRNAs in the Trabecular Meshwork [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2014 Abstract MicroRNAs (miRNAs) are now recognized as important post-transcriptional regulators of gene expression. MiRNAs are known to modulate cellular functions relevant to the normal and pathological physiology of the trabecular meshwork (TM) such as cell contraction and extracellular matrix turnover. There is also increasing evidence
Pedro, Gonzalez +4 more
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Stress Response of the Trabecular Meshwork [PDF]
Journal of Glaucoma, 2008 The trabecular meshwork (TM) is known to be subjected to different types of stress such as mechanical, oxidative, and phagocytic stress. Although short-term exposure to these stresses is expected to elicit adaptive responses, long-term exposure may lead to permanent alterations in the tissue physiology and contribute to the pathologic increase in ...
Paloma B, Liton, Pedro, Gonzalez
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Ablation of trabecular meshwork [PDF]
, 1990 An enukleierten Augen führten wir experimentelle Untersuchungen zur Ablation des Trabekelwerks (AT) durch. Eine Quarzfaser wurde durch die Vorderkammer bis zum gegenüberliegenden Trabekelwerk geführt und dieses mit einem Excimer Laser mit 248 und 308 nm ...
Vogel, Martin +4 more
core +1 more source
Extracellular matrix in the trabecular meshwork [PDF]
Experimental Eye Research, 2008 The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is regulated primarily by a fluid resistance to aqueous humor outflow. However, neither the exact site nor the identity of the normal resistance to aqueous humor outflow has been ...
Ted S, Acott, Mary J, Kelley
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Journal of Agromedicine and Medical Sciences (AMS), 2017 In primary open angle glaucoma, decrease of hyaluronic acid level is related to extracellular matrix deposition of trabecular meshwork. Extracellular matrix deposition will increase humor aqueous outflow resistance which in turn increase the intraocular ...
Cicih Komariah +2 more
doaj +1 more source
Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study. [PDF]
PLoS ONE, 2016 Myopia subjects usually have long axial lengths and are predisposed to deep anterior chamber depths and open angles. Jiangning eye study is a randomized, population based study in Shanghai to determine whether myopia has an effect on the prevalence of ...
Xiaohong Liu +9 more
doaj +1 more source