Results 41 to 50 of about 26,453 (308)

RNA interference as a gene silencing therapy for mutant MYOC protein in primary open angle glaucoma

Diagnostic Pathology, 2009
Background Primary open-angle glaucoma (POAG) is the most common form of glaucoma which is an irreversible blind leading disease and lacks effective remedies.
Sun Xinghuai, Chen Xueli, Xu Jianjiang, Li Mao   +3 more
doaj   +1 more source

Matrix Metalloproteinases and Glaucoma Treatment. [PDF]

, 2020
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed, Robinson, Michael R, Stamer, W Daniel, Weinreb, Robert N   +3 more
core  

Glycosaminoglycans in the human cornea: age-related changes [PDF]

, 2015
AIM: To investigate possible age-related changes in glycosaminoglycans (GAGs) in the human cornea. The substances today called GAGs were previously referred to as mucopolysaccharides.
Anello, Giulia, Cavallotti, Carlo, De Paolis, Giulio, Pacella, Elena, Pacella, Fernanda, Parisella, Francesca Romana, Turchetti, Paolo   +6 more
core   +2 more sources

Hyaluronan synthase in trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2003
Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
T, Usui, F, Nakajima, R, Ideta, Y, Kaji, Y, Suzuki, M, Araie, S, Miyauchi, P, Heldin, H, Yamashita   +8 more
openaire   +2 more sources

Scanning electron microscopy of the trabecular meshwork: Understanding the pathogenesis of primary angle closure glaucoma

Indian Journal of Ophthalmology, 2012
Purpose: To study ultrastructural changes of the trabecular meshwork in acute and chronic primary angle closure glaucoma (PACG) and primary open angle glaucoma (POAG) eyes by scanning electron microscopy.
Ramanjit Sihota, Amita Goyal, Jasbir Kaur, Viney Gupta, Tapas C Nag   +4 more
doaj   +1 more source

Toll-Like Receptor 4 Signaling in the Trabecular Meshwork

Frontiers in Cell and Developmental Biology, 2022
Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk, Humberto Hernandez, Thanh Le, Jose Ricardo Ramirez, Colleen M. McDowell   +4 more
doaj   +1 more source

Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress

Cells, 2022
Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver, CYP1B1 is predominantly found in extrahepatic tissues, such as the brain, and ocular tissues ...
Yong-Seok Song, Andrew J. Annalora, Craig B. Marcus, Colin R. Jefcoate, Christine M. Sorenson, Nader Sheibani   +5 more
doaj   +1 more source

Gene transfer to human trabecular meshwork cells in vitro and ex vivo using HIV-based lentivirus [PDF]

, 2014
AIM:To investigate whether the enhanced green fluorescent protein (EGFP) reporter gene could be transferred into human trabecular meshwork (HTM) cells by a HIV-based lentivirus both in vitro and ex vivo.
Li, Bin, Li, Gui-Gang, Manyande, Anne, Tian, Xuebi, Wang, Jun-Ming, Xiang, Yan, Zhang, Hong   +6 more
core   +2 more sources

Mechanism of Secondary Glaucoma Development in HTLV-1 Uveitis

Frontiers in Microbiology, 2022
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus identified as the causative agent of human diseases, such as adult T-cell leukemia, HTLV-1-associated myelopathy, and HTLV-1 uveitis (HU).
Yuan Zong, Koju Kamoi, Naoko Ando, Hisako Kurozumi-Karube, Kyoko Ohno-Matsui   +4 more
doaj   +1 more source

Mitochondrial damage in the trabecular meshwork occurs only in primary open-angle glaucoma and in pseudoexfoliative glaucoma.

PLoS ONE, 2011
BackgroundOpen-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment.
Alberto Izzotti, Mariagrazia Longobardi, Cristina Cartiglia, Sergio Claudio Saccà   +3 more
doaj   +1 more source