Results 41 to 50 of about 67,374 (288)
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
Frontiers in Cell and Developmental Biology, 2022 Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk +4 more
doaj +1 more source
Evidence for a calcification process in the trabecular meshwork [PDF]
Experimental Eye Research, 2009 The human trabecular meshwork (TM) expresses many genes that have been associated with physiological (bone, cartilage, teeth) and pathological (vascular systems, kidney) calcification. In particular, the TM highly expresses the inhibitor of calcification Matrix Gla (MGP) gene, which encodes a vitamin K-dependent protein that requires post-translational
Teresa Borrás, Núria Comes
openaire +3 more sources
Mechanism of Secondary Glaucoma Development in HTLV-1 Uveitis
Frontiers in Microbiology, 2022 Human T-cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus identified as the causative agent of human diseases, such as adult T-cell leukemia, HTLV-1-associated myelopathy, and HTLV-1 uveitis (HU).
Yuan Zong +4 more
doaj +1 more source
Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress
Cells, 2022 Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver, CYP1B1 is predominantly found in extrahepatic tissues, such as the brain, and ocular tissues ...
Yong-Seok Song +5 more
doaj +1 more source
International Journal of Molecular Medicine, 2018 Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction of the TM, potentially leading to increased IOP.
Hongwei Wang +5 more
semanticscholar +1 more source
Investigative Ophthalmology and Visual Science, 2018 Purpose The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause of irreversible blindness worldwide, is associated with changes in the ECM of the TM ...
Janice A. Vranka +7 more
semanticscholar +1 more source
PLoS ONE, 2011 BackgroundOpen-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment.
Alberto Izzotti +3 more
doaj +1 more source
Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe. [PDF]
PLoS ONE, 2013 Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an inositol polyphosphate 5-phosphatase, result in Oculocerebrorenal syndrome of Lowe, an X-linked recessive disorder that presents ...
Na Luo +5 more
doaj +1 more source
An Iconic Case of Pigmentary Glaucoma: Brief Review of the Literature
Case Reports in Ophthalmology, 2020 Pigment dispersion syndrome and pigmentary glaucoma are two conditions characterized by pigment dispersion originating from the posterior part of the iris and its accumulation on the trabecular meshwork, corneal endothelium, and anterior surface of the ...
Mariachiara Di Pippo +3 more
doaj +1 more source
Influence of Form and Structural Features of Open‐Cell Hybrid Foam on the Remanent Magnetic Scanning
Advanced Engineering Materials, EarlyView.Simulations using an equivalent model are performed to improve the understanding of remanent magnetic scanning of hybrid foam samples for coating thickness estimation. The model allows to study the influence of isolated geometrical features such as layer thickness, boundary effects, as well as effects due to the statistical nature of the foams, which ...
Bashar Ibrahim +4 more
wiley +1 more source