Results 51 to 60 of about 76,982 (335)
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
Frontiers in Cell and Developmental Biology, 2022 Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk +4 more
doaj +1 more source
Rho- Kinase Inhibitor Y-27632 Decreases the Thickness of Trabecular Meshwork in Juvenile Rats Mod-el Injected with Sodium Hyaluronate [PDF]
, 2018 Most glaucoma drugs lower the intraocular pressure (IOP) by decreasing the aqueous humor production and increasing the outflow through uveoscleral pathway. None of these drugs work mainly on increasing outflow through the trabecular pathway. Consequently,
Effendi, M. (Ma\u27sum) +3 more
core +1 more source
Where does selective laser trabeculoplasty stand now? A review [PDF]
, 2016 Background: Chronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma medication. We wondered if selective laser trabeculoplasty (SLT) could be a useful alternative.
De Belder, Maya +3 more
core +2 more sources
Matrix Metalloproteinases and Glaucoma Treatment. [PDF]
, 2020 Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed +3 more
core
Evidence for a calcification process in the trabecular meshwork [PDF]
Experimental Eye Research, 2009 The human trabecular meshwork (TM) expresses many genes that have been associated with physiological (bone, cartilage, teeth) and pathological (vascular systems, kidney) calcification. In particular, the TM highly expresses the inhibitor of calcification Matrix Gla (MGP) gene, which encodes a vitamin K-dependent protein that requires post-translational
Teresa Borrás, Núria Comes
openaire +3 more sources
Mechanism of Secondary Glaucoma Development in HTLV-1 Uveitis
Frontiers in Microbiology, 2022 Human T-cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus identified as the causative agent of human diseases, such as adult T-cell leukemia, HTLV-1-associated myelopathy, and HTLV-1 uveitis (HU).
Yuan Zong +4 more
doaj +1 more source
Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress
Cells, 2022 Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver, CYP1B1 is predominantly found in extrahepatic tissues, such as the brain, and ocular tissues ...
Yong-Seok Song +5 more
doaj +1 more source
Glaucoma and cigarette smoking: a review of narrative reviews [PDF]
, 2016 Background: Glaucoma is an optic neuropathy associated with visual field changes for which high intra-ocular pressure is a major risk factor. Emerging research indicates that modifiable factors, among which the cigarette smoke, besides IOP may be ...
DI MURRO, FRANCESCA +3 more
core +2 more sources
An Iconic Case of Pigmentary Glaucoma: Brief Review of the Literature
Case Reports in Ophthalmology, 2020 Pigment dispersion syndrome and pigmentary glaucoma are two conditions characterized by pigment dispersion originating from the posterior part of the iris and its accumulation on the trabecular meshwork, corneal endothelium, and anterior surface of the ...
Mariachiara Di Pippo +3 more
doaj +1 more source
PLoS ONE, 2011 BackgroundOpen-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment.
Alberto Izzotti +3 more
doaj +1 more source