Results 51 to 60 of about 15,874 (252)

Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells

Cells, 2021
Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma.
Mark S. Filla, Kristy K. Meyer, Jennifer A. Faralli, Donna M. Peters   +3 more
doaj   +1 more source

Biomechanical and Displacement‐Related Considerations in the Design of a 3D‐Printed Composite Energy‐Storage‐and‐Return Prosthetic Foot

Advanced Materials Technologies, EarlyView.
For the first time, Continuous Fiber‐Reinforced 3D printing is used to fabricate a foot prosthesis, exploring the flexibility in the design space granted by additive manufacturing, evaluating computationally and experimentally the effect of different design features on the mechanical and biomechanical response of the material, to locally tune the ...
Jacopo Romanò, Lorenzo Garavaglia, Abdel Rahman Nedal Al Thahabi, Luca Michele Martulli, Gennaro Rollo, Andrea Sorrentino, Fabio Lazzari, Marino Lavorgna, Andrea Bernasconi, Emanuele Gruppioni, Simone Pittaccio   +10 more
wiley   +1 more source

Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice

Communications Biology, 2022
Intraocular pressure, which can cause glaucoma, is found to be affected by nocturnal sympathetic noradrenaline, which inhibits phagocytosis in trabecular meshwork cells through β1-aderenergic receptor mediated cAMP-EPAC-SHIP1 activation.
Keisuke Ikegami, Satoru Masubuchi
doaj   +1 more source

Oxidative stress and antioxidants in the trabecular meshwork

PeerJ, 2019
Glaucoma is an age-dependent disease closely related to oxidative stress and is regarded as the second leading cause of irreversible blindness worldwide. In recent years, many studies have shown that morphological and functional abnormalities of the trabecular meshwork (TM) are closely related to glaucoma, especially with respect to oxidative stress ...
Yajuan Zheng, Mingxuan Wang
openaire   +4 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Endothelial nitric oxide synthase deficiency influences normal cell cycle progression and apoptosis in trabecular meshwork cells [PDF]

International Journal of Ophthalmology, 2016
AIM: To clarify how the endothelial nitric oxide synthase (eNOS, NOS3) make effect on outflow facility through the trabecular meshwork (TM). METHODS: Inhibition of NOS3 gene expression in human TM cells were conducted by three siRNAs.
Qiong Liao, Yan-Ming Huang, Wei Fan, Chan Li, Hong Yang   +4 more
doaj   +1 more source

Accelerating Sono‐Piezoelectric Charge Transport for Antibacterial Therapy and Bone Regeneration by Metal‐Deficient TiO2 Spin‐Polarization Effect

Advanced Science, EarlyView.
The deficient TiO2 (DTO) and Barium titanate (BTO) heterojunction treats osteomyelitis through SDT. The spin‐polarization effect induced by the unpaired spin electrons in Ti atoms can expedite the transfer of ultrasonic piezoelectric charges in BTO, enhancing surface sonocatalytic efficiency.
Chaofeng Wang, Shuilin Wu, Congyang Mao, Liguo Jin, Hanpeng Liu, Yufeng Zheng, Chunyong Liang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Xiangmei Liu   +10 more
wiley   +1 more source

The trabecular meshwork in acute and chronic angle closure glaucoma.

Indian Journal of Ophthalmology, 2001
PURPOSE: To determine the effect of acute and chronic primary angle closure glaucoma (PACG) on the trabecular meshwork. METHODS: Trabecular specimens of 16 consecutive patients with primary angle closure glaucoma (PACG)--6 acute PACG eyes, and 10 chronic
Sihota R, Lakshmaiah N, Walia K, Sharma S, Pailoor J, Agarwal H   +5 more
doaj  

Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients

BMC Ophthalmology, 2018
Background The pathophysiological changes occurring in the trabecular meshwork in primary open angle glaucoma are poorly understood, but are thought to include increased extracellular matrix deposition, trabecular meshwork cell apoptosis, inflammation ...
Esther L. Ashworth Briggs, Tze’Yo Toh, Rajaraman Eri, Alex W. Hewitt, Anthony L. Cook   +4 more
doaj   +1 more source

TIPARP is involved in the regulation of intraocular pressure

Communications Biology, 2022
TIPARP, an inducible poly-ADP-ribose polymerase, is identified as a novel regulator of intraocular pressure through modulation of extracellular matrix and cell cytoskeleton proteins in trabecular meshwork cells.
Youjia Zhang, Maomao Song, Yingwen Bi, Yuan Lei, Xinghuai Sun, Yuhong Chen   +5 more
doaj   +1 more source