Results 51 to 60 of about 26,453 (308)

Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes. [PDF]

, 2016
PurposeWe characterize aqueous angiography as a real-time aqueous humor outflow imaging (AHO) modality in cow eyes with two tracers of different molecular characteristics.MethodsCow enucleated eyes (n = 31) were obtained and perfused with balanced salt ...
Begian, Alan, Caprioli, Joseph, Dastiridou, Anna, Francis, Brian A, Hinton, David R, Huang, Alex S, Legaspi, Hanz, Mohindroo, Chirayu, Saraswathy, Sindhu, Tan, James CH, Weinreb, Robert N   +10 more
core   +3 more sources

Biological properties of trabecular meshwork cells [PDF]

Experimental Eye Research, 2009
The molecular and physiological mechanisms that lead to the progression of glaucoma are poorly understood. Despite the fact that glaucoma afflicts millions of people worldwide, research on the disease is limited by the current animal models that do not translate well to human forms of the disease.
Joshua Z, Gasiorowski, Paul, Russell
openaire   +2 more sources

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe. [PDF]

PLoS ONE, 2013
Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an inositol polyphosphate 5-phosphatase, result in Oculocerebrorenal syndrome of Lowe, an X-linked recessive disorder that presents ...
Na Luo, Akhilesh Kumar, Michael Conwell, Robert N Weinreb, Ryan Anderson, Yang Sun   +5 more
doaj   +1 more source

A laser-induced mouse model with long-term intraocular pressure elevation [PDF]

, 2014
Purpose: To develop and characterize a mouse model with intraocular pressure (IOP) elevation after laser photocoagulation on the trabecular meshwork (TM), which may serve as a model to investigate the potential of stem cell-based therapies for glaucoma ...
Du, Y, Fu, V, Kagemann, L, Lathrop, KL, Schuman, JS, Stolz, DB, Sun, M, Yang, E, Yun, H   +8 more
core   +3 more sources

Stress Response of the Trabecular Meshwork [PDF]

Journal of Glaucoma, 2008
The trabecular meshwork (TM) is known to be subjected to different types of stress such as mechanical, oxidative, and phagocytic stress. Although short-term exposure to these stresses is expected to elicit adaptive responses, long-term exposure may lead to permanent alterations in the tissue physiology and contribute to the pathologic increase in ...
Paloma B, Liton, Pedro, Gonzalez
openaire   +2 more sources

Pharmacologic Manipulation of Conventional Outflow Facility in Ex Vivo Mouse Eyes [PDF]

, 2012
PURPOSE. Mouse models are useful for glaucoma research, but it is unclear whether intraocular pressure (IOP) regulation in mice operates through mechanisms similar to those in humans.
Bertrand, J, Boussommier-Calleja, A, Ethier, CR, Overby, DR, Stamer, WD, Woodward, DF   +5 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Similar Performance of Trabectome and Ahmed Glaucoma Devices in a Propensity Score-matched Comparison [PDF]

, 2018
Purpose: To apply propensity score matching to Ahmed glaucoma drainage implants (AGI) to trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggest that AIT can produce results similar to AGI traditionally reserved for more severe glaucoma.
Ahuja, Al-Torbak, Behndig, Brubaker, Budenz, Bussel, Bussel, Cha, Christakis, Coleman, Cox, Dang, Dang, Fallano, Francis, Gedde, Gedde, Hong, Iacus, Iacus, Iordanous, Jea, Kaplan, Kaplowitz, Kim, Krupin, Loewen, Loewen, Loewen, Maeda, Minckler, Mosaed, Mosaed, Neiweem, Parikh, Parikh, Rosenbaum, Roy, Rubin, Seeger, Ting, Vold, Xin   +42 more
core   +1 more source

Senescence in cultured trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2007
It has been suggested that replicative senescence might be involved in the pathophysiology of age-related diseases.To study the process of senescence in trabecular meshwork (TM) cells.Porcine TM tissues were obtained and placed in primary cultures with Dulbecco's modified Eagle's medium/Ham's F-12 medium.
Yukari, Yamazaki, Hiroshi, Matsunaga, Maki, Nishikawa, Akira, Ando, Shiho, Kaneko, Koji, Okuda, Mitsumasa, Wada, Seiji, Ito, Miyo, Matsumura   +8 more
openaire   +2 more sources

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

Advanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer, Arundhati Joshi, Constantin von Kaisenberg, Dorothea Brüggemann, Cornelia Lee‐Thedieck   +4 more
wiley   +1 more source