Results 71 to 80 of about 78,864 (334)

A laser-induced mouse model with long-term intraocular pressure elevation [PDF]

, 2014
Purpose: To develop and characterize a mouse model with intraocular pressure (IOP) elevation after laser photocoagulation on the trabecular meshwork (TM), which may serve as a model to investigate the potential of stem cell-based therapies for glaucoma ...
Du, Y, Fu, V, Kagemann, L, Lathrop, KL, Schuman, JS, Stolz, DB, Sun, M, Yang, E, Yun, H   +8 more
core   +3 more sources

Canaloplasty: current value in the management of glaucoma [PDF]

, 2016
Canaloplasty is a nonpenetrating blebless surgical technique for open-angle glaucoma, in which a flexible microcatheter is inserted within Schlemm's canal for the entire 360 degrees. When the microcatheter exits the opposite end, a 10-0 prolene suture is
Cagini, Carlo, Fiore, Tito, Lippera, Myrta, Lippera, Stefano, Peruzzi, Claudia, Spadea, Leopoldo   +5 more
core   +3 more sources

In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Glaucoma is the leading cause of irreversible blindness worldwide. The primary and only modifiable risk factor for the development of glaucoma is elevated intraocular pressure (IOP), and lowering IOP effectively slows glaucomatous disease ...
Guorong Li, Chanyoung Lee, Vibhuti Agrahari, Ke Wang, I. Navarro, J. Sherwood, Karen E. Crews, Sina Farsiu, P. Gonzalez, Cheng-Wen Lin, A. Mitra, C. Ethier, W. Stamer   +12 more
semanticscholar   +1 more source

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe. [PDF]

PLoS ONE, 2013
Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an inositol polyphosphate 5-phosphatase, result in Oculocerebrorenal syndrome of Lowe, an X-linked recessive disorder that presents ...
Na Luo, Akhilesh Kumar, Michael Conwell, Robert N Weinreb, Ryan Anderson, Yang Sun   +5 more
doaj   +1 more source

Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure. [PDF]

, 2017
This work was funded by National Institute of Health Grants R01 EY016112, EY015266, and EY014801 and an unrestricted grant to the University of Miami's Bascom Palmer Eye Institute from Research to Prevent Blindness. Financial support from Fight for Sight
Bhattacharya, Sanjoy K., Carreon, Teresia A., Castellanos, Aida, Gasull Casanova, Xavier   +3 more
core   +1 more source

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)

International Journal of Molecular Medicine, 2018
Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction of the TM, potentially leading to increased IOP.
Hongwei Wang, Mingzhe Li, Zhenzhen Zhang, Hai-feng Xue, Xing Chen, Yong Ji   +5 more
semanticscholar   +1 more source

Bone‐Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker, Luke Hipwood, Akhilandeshwari Ravichandran, Dietmar W. Hutmacher, Christoph Meinert, Jacqui McGovern   +5 more
wiley   +1 more source

An Iconic Case of Pigmentary Glaucoma: Brief Review of the Literature

Case Reports in Ophthalmology, 2020
Pigment dispersion syndrome and pigmentary glaucoma are two conditions characterized by pigment dispersion originating from the posterior part of the iris and its accumulation on the trabecular meshwork, corneal endothelium, and anterior surface of the ...
Mariachiara Di Pippo, Chiara Ciancimino, Luca Scuderi, Andrea Perdicchi   +3 more
doaj   +1 more source

Similar Performance of Trabectome and Ahmed Glaucoma Devices in a Propensity Score-matched Comparison [PDF]

, 2018
Purpose: To apply propensity score matching to Ahmed glaucoma drainage implants (AGI) to trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggest that AIT can produce results similar to AGI traditionally reserved for more severe glaucoma.
Ahuja, Al-Torbak, Behndig, Brubaker, Budenz, Bussel, Bussel, Cha, Christakis, Coleman, Cox, Dang, Dang, Fallano, Francis, Gedde, Gedde, Hong, Iacus, Iacus, Iordanous, Jea, Kaplan, Kaplowitz, Kim, Krupin, Loewen, Loewen, Loewen, Maeda, Minckler, Mosaed, Mosaed, Neiweem, Parikh, Parikh, Rosenbaum, Roy, Rubin, Seeger, Ting, Vold, Xin   +42 more
core   +1 more source

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, EarlyView.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source