Results 91 to 100 of about 5,722,533 (317)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ask an expert: why do tides vary regionally?

Ashton (7, UK) asks Sunke Trace-Kleeberg why tides can vary so much from one location to another.
Trace-Kleeberg, Sunke
core   +1 more source

The Microbiome of the Gastrointestinal Tract of a Range-Shifting Marine Herbivorous Fish

Frontiers in Microbiology, 2018
Globally, marine species’ distributions are being modified due to rising ocean temperatures. Increasing evidence suggests a circum-global pattern of poleward extensions in the distributions of many tropical herbivorous species, including the ecologically
Jacquelyn Jones, Joseph D. DiBattista, Joseph D. DiBattista, Michael Stat, Michael Stat, Michael Bunce, Mary C. Boyce, David V. Fairclough, Michael J. Travers, Megan J. Huggett, Megan J. Huggett, Megan J. Huggett   +11 more
doaj   +1 more source

Solution to a case involving the interpretation of trace degraded DNA mixtures

Zeitschrift für Rechtsmedizin
DNA mixture analysis poses a significant challenge in forensic genetics, particularly when dealing with degraded and trace amount DNA samples. Multi-SNPs (MNPs) are genetic markers similar to microhaplotypes but with smaller molecular sizes (
Ji Chen, Anqi Chen, Ruiyang Tao, Ruxin Zhu, Han Zhang, Xuechun You, Cheng-Tao Li, Suhua Zhang   +7 more
semanticscholar   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Far away from home? Ancient DNA shows the presence of bicolored shrew (Crocidura leucodon) in Bronze Age Denmark

Ecology and Evolution
An excavation of an Early Iron Age village near Aalborg in Denmark uncovered the jaws and skull fragments from a small mammal that were morphologically identified to the genus Crocidura (white‐toothed shrews).
Mahsa Mousavi‐Derazmahalleh, Niels Haue, Marie Kanstrup, Jørgen T. Laursen, Sherralee S. Lukehurst, Jacob Kveiborg, Morten E. Allentoft   +6 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

qPCR‐Based Environmental DNA (eDNA) Detection of Cryptic Arboreal Species Interaction With Artificial Habitat Structures

Environmental DNA
Effective restoration of anthropogenically impacted sites requires continued monitoring of faunal species return, but restoration sites often lack mature habitat structures that many species rely on.
Austin M. Guthrie, Christine E. Cooper, Philip W. Bateman, Mieke van derHeyde, Paul Bullock, Paul Nevill   +5 more
doaj   +1 more source

Analysing the effects of distance, taxon and biomass on vertebrate detections using bulk-collected carrion fly iDNA

Royal Society Open Science
Invertebrate-derived DNA (iDNA) metabarcoding from carrion flies is a powerful, non-invasive tool that has value for assessing vertebrate diversity. However, unknowns exist around the factors that influence vertebrate detections, such as spatial limits ...
Kristen Fernandes, Philip W. Bateman, Benjamin J. Saunders, Mark Gibberd, Michael Bunce, Kristine Bohmann, Paul Nevill   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source