Results 81 to 90 of about 5,722,533 (317)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Using eDNA metabarcoding to understand the effect of fire on the diet of small mammals in a woodland ecosystem

Ecology and Evolution, 2022
Food acquisition is a fundamental process that drives animal distribution and abundance, influencing how species respond to changing environments. Disturbances such as fire create significant shifts in available dietary resources, yet, for many species ...
Saumya Wanniarachchi, Matthew Swan, Paul Nevil, Alan York   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

epiverse-trace/blueprints: 0.0.2

, 2022
What's Changed Add policy regarding code re-use, crediting and license compatibility by @jpavlich in https://github.com/epiverse-trace/blueprints/pull/4 Convert blueprints to quarto book by @Bisaloo in https://github.com/epiverse-trace/blueprints/pull ...
Thibaut Jombart, Jaime Pavlich-Mariscal, Hugo Gruson, actions-user   +3 more
core   +1 more source

Species‐level biodiversity assessment using marine environmental DNA metabarcoding requires protocol optimization and standardization

Ecology and Evolution, 2019
DNA extraction from environmental samples (environmental DNA; eDNA) for metabarcoding‐based biodiversity studies is gaining popularity as a noninvasive, time‐efficient, and cost‐effective monitoring tool.
Gert‐Jan Jeunen, Michael Knapp, Hamish G. Spencer, Helen R. Taylor, Miles D. Lamare, Michael Stat, Michael Bunce, Neil J. Gemmell   +7 more
doaj   +1 more source

Estuarine fishes associated with intertidal oyster reefs characterized using environmental DNA and baited remote underwater video

Environmental DNA, 2022
It has been widely shown that oyster reefs enhance local biodiversity and fisheries production. To determine the importance of intertidal remnant estuarine oyster reefs compared to unstructured sandy habitats over small spatial scales (
Victoria J. Cole, David Harasti, Rose Lines, Michael Stat   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A quantitative analysis of vertebrate environmental DNA degradation in soil in response to time, UV light, and temperature

Environmental DNA
Environmental DNA (eDNA) degradation influences the effectiveness of eDNA‐based biodiversity monitoring, but the factors that determine the rate of decay of eDNA in terrestrial environments are poorly understood. We assessed the persistence of vertebrate
Austin M. Guthrie, Christine E. Cooper, Philip W. Bateman, Mieke van derHeyde, Morten E. Allentoft, Paul Nevill   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Evidence for fungi and gold redox interaction under Earth surface conditions

Nature Communications, 2019
The role of fungi in the biogeochemical cycling of gold remains unclear. Here the authors show that fungi can initiate gold oxidation under supergene conditions, thereby impacting gold mobilisation and secondary deposit formation in terrestrial ...
Tsing Bohu, Ravi Anand, Ryan Noble, Mel Lintern, Anna H. Kaksonen, Yuan Mei, Ka Yu Cheng, Xiao Deng, Jean-Pierre Veder, Michael Bunce, Matthew Power, Mike Verrall   +11 more
doaj   +1 more source