Results 201 to 210 of about 9,930 (290)

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Case Report: Behavioral analysis guided intervention targeting triggers and urges in skin-picking disorder with comorbid onychophagia. [PDF]

Front Psychiatry
Kawahito M, Murayama K, Tomiyama H, Kato K, Nakao T.   +4 more
europepmc   +1 more source

Local Polarization Unit Engineering Enables Ultrahigh Energy Density in NBT‐Based High‐Entropy Ceramic Capacitors

Advanced Science, EarlyView.
Herein, we demonstrate a breakthrough in dielectric energy storage by engineering local polarization units in high‐entropy multilayer ceramic capacitors (MLCCs). The optimized MLCCs achieve an ultrahigh recoverable energy density of 18.2 J cm−3 with 91% efficiency, coupled with exceptional thermal stability and fatigue resistance.
Shiyu Zhou, Yucheng Zhou, Linhai Li, A. Pelaiz‐Barranco, Xuefeng Chen, Genshui Wang, Yiwei Chen, Rongjiang Wang, Konstantin Nefedev, Tengfei Hu, Dawei Wang, Tongqing Yang   +11 more
wiley   +1 more source

Exploring seismic warning thresholds for vehicle-track systems through combined shaking table tests and dynamic numerical simulations. [PDF]

Sci Rep
Li H, Zhang H, Pan H.
europepmc   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

Optimizing transducer choice for the detection of alveolar-interstitial syndrome in dogs and cats: an evidence-based review. [PDF]

Front Vet Sci
Granger KL, Riffe CI, Boysen SR, Talbot CT.   +3 more
europepmc   +1 more source

Architecture‐Controlled Hierarchical Carbon‐Based Current Collector for Mitigating Interfacial Instabilities in Lithium‐Metal Anodes

Advanced Science, EarlyView.
A defect‐engineered, hierarchically porous carbon black/CNT current collector guides lithiophilic nucleation in 3D architecture. Steam‐created defects enable uniform Li plating, while CNTs provide conductivity and a lightweight framework, suppressing dendrites and side reactions for stable anode‐free cells.
Seo Hui Kang, Dong Hyeon Hwa, Ji Su Chae, Kwang Chul Roh   +3 more
wiley   +1 more source

Multi-parameter and multi-objective collaborative optimization of a suspended monorail vehicle addressing its strongly coupled nonlinear characteristics. [PDF]

Sci Rep
Jiang Y, Zhang S, Liu W, Chen R, Wang Q.
europepmc   +1 more source

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids

Advanced Science, EarlyView.
A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim, Yoojeong Kim, Jun Sun, Il‐Joo Cho, Joseph A. Gogos, Jong‐Chan Park, C‐Yoon Kim, Hyunjoo J. Lee   +10 more
wiley   +1 more source

Toward Smart Railway Infrastructure Predictive and Optimised Maintenance Through Digital Twin (DT) System. [PDF]

Sensors (Basel)
Kazemi MJ, Rashidi M, Kang WH, Siahkouhi M.   +3 more
europepmc   +1 more source