Results 41 to 50 of about 72,133 (284)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

A brief history: Traditional Chinese medicinal system

Pharmacological Research - Modern Chinese Medicine
Introduction: Traditional Chinese medicine (TCM), one of the main modern alternative therapies, is still widely used in Chinese communities and is starting to get scholarly recognition in the field of western medicine.
Rishabh Gaur
doaj   +1 more source

Clinical Practice Guidelines of Chinese Medicine Rehabilitation for Ischemic Stroke （Cerebral Infarction）Working Group of Clinical Practice Guidelines of Chinese Medicine Rehabilitation for Ischemic Stroke (Cerebral Infarction)

康复学报, 2021
Ischemic stroke (cerebral infarction) is a common clinical disease of ischemic necrosis or softening of localized brain tissue, which belongs to "stroke disease" in traditional Chinese medicine (TCM).
Working Group of Clinical Practice Guidelines of Chinese Medicine Rehabilitation for Ischemic Stroke (Cerebral Infarction)
doaj  

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

AI drug discovery tools and analysis technology: New methods aid in studying the compatibility of Traditional Chinese Medicine

Pharmacological Research - Modern Chinese Medicine
Introduction: The compatibility of Traditional Chinese Medicine (TCM) holds the potential for reducing toxicity and enhancing efficacy, serving as a crucial guide for the clinical application of TCM.
Qiwu Jiang, Suhan Yang, Shan He, Fei Li
doaj   +1 more source

Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation

Frontiers in Chemistry, 2021
In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A–D (1–4), eurylosesquiterpenols E–I (5–9), and ten known ones (10–
Jiejing Yan, Mimi Hao, Yu Han, Jingya Ruan, Dandan Zheng, Fan Sun, Huina Cao, Jia Hao, Yi Zhang, Yi Zhang, Tao Wang, Tao Wang   +11 more
doaj   +1 more source

Identification of Potent EGFR Inhibitors from TCM Database@Taiwan [PDF]

, 2011
Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells.
AE Wakeling, AM Petit, AN de Oliveira, AS El-Azab, B Forsythe, B Linggi, BR Brooks, Calvin Yu-Chian Chen, CH Hsu, CH Yun, Consortium The UniProt, CY Chen, CYC Chen, FA Pasha, FG Pernas, HB Shen, HI Ali, HJ Huang, Hsin-Yi Chen, James M. Briggs, K Choowongkomon, K Oda, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, L Chen, M Krug, M Mustafa, M Van den Eynde, MS Coumar, P Wang, PC Lv, Pharmaceuticals AustraZeneca, PJ Medina, QH Liao, R Sordella, RE Fan, RR Picard, RS Herbst, S Nandi, SD Fidanze, SH Liu, Shun-Chieh Yang, SI Sherman, SM Abou-Seri, SP Either, SR Johnston, Su-Sen Chang, T Huang, T Mitsudomi, T Shibata, TO Chan, V Merlo, VB Konkimalla, WA Franklin, WY Cheng, Y Qian, Y Zheng   +61 more
core   +3 more sources

Chinese Medicine Student Clubs in Taipei, Taiwan [PDF]

, 2020
This thesis focuses on a communal form of transmission of Chinese medicine in contemporary Taiwan: Chinese medicine university student clubs. Offering fundamental Chinese medicine curricula to students and the interested public, the student clubs used to
Buchner, Karoline
core   +1 more source

Multifunctional Gelatin‐Based Smart Films Integrating Thermochromic Encryption, Temperature‐Regulated Photothermal Management, Reprocessability, and Biodegradability for Sustainable Applications

Advanced Science, EarlyView.
Multifunctional gelatin films synergizing thermochromic encryption, self‐regulating photothermal management, and closed‐loop recyclability offer sustainable solutions for intelligent packaging. ABSTRACT Multifunctional gelatin‐based smart films are engineered by incorporating hyperbranched polyglycerol (HBPG) as a plasticizer, dialdehyde β‐cyclodextrin
Yuehong Zhang, Chen Yang, Langlang Dai, Leipeng Liu, Vijay Kumar Thakur   +4 more
wiley   +1 more source

When the East Meets the West: the Future of Traditional Chinese Medicine in the 21st Century

康复学报, 2016
Traditional Chinese medicine (TCM) has a history of thousands of years, is a very valuable treasure left by our ancestors, and there are many things which are worth our in-depth mining. But in the past hundreds of years, with the Western medicine came to
Jin QIU
doaj