Results 171 to 180 of about 164,752 (316)

A hybrid multicommodity routing algorithm for traffic engineering [PDF]

, 2004
Wided Ouaja, Barry Richards
openalex   +1 more source

Erythropoietin‐Stimulated Macrophage‐Derived Extracellular Vesicles in Chitosan Hydrogel Rescue BMSCs Fate by Targeting EGFR to Alleviate Inflammatory Bone Loss in Periodontitis

Advanced Science, EarlyView.
A therapeutic strategy is proposed for periodontitis using extracellular vesicles derived from EPO‐stimulated macrophages (EPO‐EVs). This schema demonstrates how EPO‐EVs enhance the osteogenic activity of mBMSCs in an inflammatory environment by inhibiting EGFR.
Shuchen Liu, Zhuoran Wang, Yuhuan Li, Ziyi Pan, Lei Huang, Jing Cui, Xue Zhang, Mingxi Yang, Yuan Zhang, Daowei Li, Hongchen Sun   +10 more
wiley   +1 more source

The Role of MCPIP1 in Macrophage Polarization and Cardiac Function Post‐Myocardial Infarction

Advanced Science, EarlyView.
Following myocardial infarction, MCPIP1 deficiency in macrophages triggers ferroptosis, driving proinflammatory M1 dominance over reparative M2 phenotypes. This imbalance amplifies splenic monocyte release and sustains cardiac inflammation. Concurrently, excessive inflammatory mediators and insufficient TGF‐β impair fibroblast activation, delaying ...
Xingxu Zhang, Yuan Fang, Xiaoming Qin, Yiwei Zhang, Bo Kang, Li Zhong, Baoxin Liu, Jiachen Luo, Yidong Wei   +8 more
wiley   +1 more source

New scheme for IP routing and traffic engineering [PDF]

, 2004
G.P. Saraph, Parwinder Singh
openalex   +1 more source

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren, Zeda Zhao, Yuqing Chao, Panting Yu, Zhoufang Mei, Bing Du, Yiyun Cheng   +6 more
wiley   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Multicast reliable traffic engineering technique for SDN-Fog based IoUT. [PDF]

Sci Rep
Mohammadi R.
europepmc   +1 more source

Effective bandwidth for traffic engineering

, 2002
R Kunz, Seth James Nielson, Michel Clément, Quinn Snell   +3 more
openalex   +2 more sources

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Fluorine‐Directed Automated Mannoside Assembly

Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023
Motivated by the importance of fluorination in drug discovery, fluorine‐directed automated glycan assembly (AFGA) is disclosed. This strategy leverages the C(sp3)−F bond at C2 to enable α‐stereocontrolled glycosylation that eliminates the reliance on O‐based directing groups.
Charlotte S. Teschers, Ryan Gilmour
wiley   +1 more source