Results 61 to 70 of about 19,676 (308)

Energy-Aware Traffic Engineering [PDF]

, 2010
Energy consumption of the Internet is already substantial and it is likely to increase as operators deploy faster equipment to handle popular bandwidth-intensive services, such as streaming and video-on-demand.
Dejan Kostić, Nedeljko Vasić, Vasic, Nedeljko, Kostic, Dejan   +3 more
core   +1 more source

Exploring the effects of measures of performance and calibration strategies on calibrating traffic microsimulation model: A quantitative analysis approach

IET Intelligent Transport Systems, 2023
In the subject of traffic microsimulation model (TMM) calibration, measure of performance (MoP) plays an essential role. However, due to the diversity of MoP types, choosing a MoP or MoP combination (usually used for multi‐criteria calibration strategy ...
Haoran Li, Zhenzhou Yuan, Siyuan Chen, Chuang Zhu   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Improving vehicle re‐identification using CNN latent spaces: Metrics comparison and track‐to‐track extension

IET Computer Vision, 2021
Herein, the problem of vehicle re‐identification using distance comparison of images in CNN latent spaces is addressed. First, the impact of the distance metrics, comparing performances obtained with different metrics is studied: the minimal Euclidean ...
Geoffrey Roman‐Jimenez, Patrice Guyot, Thierry Malon, Sylvie Chambon, Vincent Charvillat, Alain Crouzil, André Péninou, Julien Pinquier, Florence Sedes, Christine Sénac   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Network Performance Implications of Variability in Data Traffic. [PDF]

, 2000
World Wide Web (WWW) traffic will dominate network traffic for the foreseeable future. Accurate predictions of network performance can only be achieved if network models reflect WWW traffic statistics.
Roadknight, Chris, Marshall, Ian W., Bilchev, George   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Enhanced motorway capacity estimation considering the impact of vehicle length on the fundamental diagram

IET Intelligent Transport Systems
The ability to understand the underlying fundamentals of traffic flow behaviour facilitates improved planning and decision‐making for road operators.
Erik Giesen Loo, Robert Corbally, Lewis Feely, Andrew O'Sullivan   +3 more
doaj   +1 more source

Towards a digital twin for supporting multi-agency incident management in a smart city

Scientific Reports, 2022
Cost-effective on-demand computing resources can help to process the increasing number of large, diverse datasets generated from smart internet-enabled technology, such as sensors, CCTV cameras, and mobile devices, with high temporal resolution. Category
Kristina Wolf, Richard J. Dawson, Jon P. Mills, Phil Blythe, Jeremy Morley   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source