Results 61 to 70 of about 7,105,066 (255)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Assessment dynamic ratio for traffic loading on highway bridges [PDF]

, 2011
The determination of characteristic bridge load effect is a complex problem. Usually, statistical extrapolation of simulated static load effects is used to derive a lifetime characteristic static load effect.
O\u27Brien, Eugene J., O'Brien, Eugene J., Rattigan, Paraic, González, Arturo, Caprani, Colin C.   +4 more
core   +1 more source

An HSS‐based robust and lightweight multiple group authentication for ITS towards 5G

IET Intelligent Transport Systems, 2021
The next generation of network communications (5G) has the particularity of being heterogeneous, which has different abilities with storage, computing and communication. Group communications is more and more popular for Intelligent Transportation Systems
Chingfang Hsu, Lein Harn, Zhe Xia
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Hierarchical wireless framework for real-time collaborative generation and distribution of telemetry data [PDF]

, 2010
This project introduces a novel multidisciplinary approach combining Vehicular Ad Hoc Networks and Granular Computing, to the data processing and information generation problem in large urban traffic systems.
Kucukdurgut, I
core  

Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane, Salama Makni, Mourad Kchaou, Ahmed El Hajjaji   +3 more
wiley   +1 more source

Exploring older driver crash trend: New Jersey case study

The Journal of Engineering, 2014
Older drivers age 65 and above are known to experience greater risk on the roadway as well as increasing the risk to other roadway users. Within the next 20 years, their population is expected to increase from 41 million in 2011 to 70 million in 2030. To
Vanvi Trieu, Seri Park, John McFadden
doaj   +1 more source

Air‐Pressure–Actuated Vibroacoustic Metamaterial With Tunable Bandgap: Design, Modeling, and Characterization

Advanced Engineering Materials, EarlyView.
This article presents the design, modeling, and characterization of air‐pressure–actuated programmable vibroacoustic metamaterials (PVAMM). The study focuses on leveraging air pressure to dynamically tune resonance frequencies for effective noise attenuation.
William Kaal, Michael M. Becker, Sarah C. L. Fischer   +2 more
wiley   +1 more source

Data Analytics Techniques for Addressing Cloud Computing Resources Allocation Challenges: A Bibliometric Analysis Approach

Journal of Information Systems and Informatics
The increase in the use of digital technology led to an increase in online activities. In this regard, many organizations adopted cloud computing systems to manage this online traffic.
Sello Prince Sekwatlakwatla, Vusumuzi Malele   +1 more
doaj   +1 more source