Results 41 to 50 of about 7,105,066 (255)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Characteristic dynamic traffic load effects in bridges [PDF]

open access: yes, 2009
When formulating an approach to assess bridge traffic loading with allowance for Vehicle-Bridge Interaction (VBI), a trade-off is necessary between the limited accuracy and computational demands of numerical models and the limited time periods for which ...
O\u27Brien, Eugene J.   +10 more
core   +1 more source

Vehicular task scheduling strategy with resource matching computing in cloud‐edge collaboration

open access: yesIET Collaborative Intelligent Manufacturing, 2021
In future transportation, on board unit (OBU) is a key component of connected vehicles with limited computing resources, and may not tackle the heavy computing burden from V2X networks.
Fangyi Hu   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Multicast traffic aggregation in MPLS-based VPN networks [PDF]

open access: yes, 2007
This article gives an overview of the current practical approaches under study for a scalable implementation of multicast in layer 2 and 3 VPNs over an IP-MPLS multiservice network. These proposals are based on a well-known technique: the aggregation of
Soto Campos, Ignacio   +6 more
core   +2 more sources

Exploring the effects of measures of performance and calibration strategies on calibrating traffic microsimulation model: A quantitative analysis approach

open access: yesIET Intelligent Transport Systems, 2023
In the subject of traffic microsimulation model (TMM) calibration, measure of performance (MoP) plays an essential role. However, due to the diversity of MoP types, choosing a MoP or MoP combination (usually used for multi‐criteria calibration strategy ...
Haoran Li   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Traffic control signal design manual

open access: yes, 2009
Title from PDF cover (DOT web site, viewed Dec. 3, 2009).; Previously published: Manual of traffic control signal design. [Wethersfield, Conn] : Dept. of Transportation, Bureau of Highways, Office of Engineering, Division of Traffic, [1984].; Includes ...

core   +1 more source

Improving vehicle re‐identification using CNN latent spaces: Metrics comparison and track‐to‐track extension

open access: yesIET Computer Vision, 2021
Herein, the problem of vehicle re‐identification using distance comparison of images in CNN latent spaces is addressed. First, the impact of the distance metrics, comparing performances obtained with different metrics is studied: the minimal Euclidean ...
Geoffrey Roman‐Jimenez   +9 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

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