Results 71 to 80 of about 269,097 (289)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source

Two Modifications of MinSum Algorithm for Efficient System-Optimal Traffic Assignment

Algorithms
Traffic assignment in large urban areas is an old but increasingly important problem because of the rapid growth of the world population and traffic demands.
Nikica Hlupić, Danko Basch, Edouard Ivanjko, Martin Gregurić   +3 more
doaj   +1 more source

Phase Change Material‐Driven Tunable Metasurface for Adaptive Terahertz Sensing and Communication in 6G Perceptive Networks

Advanced Functional Materials, EarlyView.
This study explores the benefits of metasurfaces made from functional materials, highlighting their ability to be adapted and improved for various high‐frequency applications, including communications and sensing. It first demonstrates the potential of these functional material‐based metasurfaces to advance the field of sub‐THz perceptive networks ...
Yat‐Sing To, Jiachen Du, Cyril Decroze, Laure Huitema, Aurelian Crunteanu, Hang Wong   +5 more
wiley   +1 more source

Exploring older driver crash trend: New Jersey case study

The Journal of Engineering, 2014
Older drivers age 65 and above are known to experience greater risk on the roadway as well as increasing the risk to other roadway users. Within the next 20 years, their population is expected to increase from 41 million in 2011 to 70 million in 2030. To
Vanvi Trieu, Seri Park, John McFadden
doaj   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

Data Analytics Techniques for Addressing Cloud Computing Resources Allocation Challenges: A Bibliometric Analysis Approach

Journal of Information Systems and Informatics
The increase in the use of digital technology led to an increase in online activities. In this regard, many organizations adopted cloud computing systems to manage this online traffic.
Sello Prince Sekwatlakwatla, Vusumuzi Malele   +1 more
doaj   +1 more source

Real-time detection of traffic congestion based on trajectory data

The Journal of Engineering, 2019
Traffic congestion is common in most cities. It not only affects people's normal travel time but also causes more traffic crashes. To solve the traffic congestion and reduce the corresponding hazards, it is necessary to quickly detect the location of ...
Qing Yang, Zhongwei Yue, Ru Chen, Jingwei Zhang, Xiaoli Hu, Ya Zhou   +5 more
doaj   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Golden‐Ratio–Guided Aperiodic Architected Metamaterials with Simultaneously Enhanced Strength and Toughness

Advanced Functional Materials, EarlyView.
Guided by the golden ratio, a class of aperiodic architected metamaterials is introduced to address the intrinsic trade‐off between strength and toughness. By unifying local geometric heterogeneity with global order, the golden‐ratio‐guided aperiodic architecture promotes spatial delocalization of damage tolerence regions, leading to more tortuous ...
Junjie Deng, Xinxin Wang, Ruochao Zhao, Zhendong Li, Kai Liu, Ke Yuan, Jia An, Xinwei Li, Chee Kai Chua, Zhonggang Wang   +9 more
wiley   +1 more source