Results 51 to 60 of about 784,260 (281)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Effect of Pilot Reaction Time and Line-Up Time on Runway Occupancy Time Take-Off about Runway Capacity (Case Study: Soekarno-Hatta International Airport)

Rekayasa Sipil
One way to increase runway capacity is to set the Runway Occupancy Time Take-Off (ROTT) standard. Following the Aeronautical Information Publication of Soekarno-Hatta International Airport, the ROTT standard is set at 90 seconds.
Mohammad Ardiansyah Putra Indrawan, Lina Rosmayanti, Yudha Abimanyu   +2 more
doaj   +1 more source

Interpreting the Wide Scattering of Synchronized Traffic Data by Time Gap Statistics

, 2004
Based on the statistical evaluation of experimental single-vehicle data, we propose a quantitative interpretation of the erratic scattering of flow-density data in synchronized traffic flows.
B.S. Kerner, B.S. Kerner, B.S. Kerner, B.S. Kerner, B.S. Kerner, B.S. Kerner, B.S. Kerner, B.S. Kerner, B.S. Kerner, C. Wagner, D. Chowdhury, D. Helbing, D. Helbing, D. Helbing, D. Helbing, Dirk Helbing, E. Tomer, H.Y. Lee, I. Lubashevsky, I.D. Couzin, J. Dzubiella, J.H. Banks, J.H. Banks, Katsuhiro Nishinari, L. Neubert, M. Treiber, M. Treiber, Martin Treiber, N. Mitarai, P. Nelson, P. Nelson, S. Krauß, T. Nagatani, W. Knospe   +33 more
core   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Visualization and Analysis of Traffic Flow and Congestion in India

Infrastructures, 2021
The paper takes an analysis of traffic conditions in a developing country, namely, India. India is a country with a rapidly growing economy and a large market, and it has the second largest population in the world, which was 1.3 billion in 2018.
Tsutomu Tsuboi
doaj   +1 more source

Synchronized flow and wide moving jams from balanced vehicular traffic

, 2005
Recently we proposed an extension to the traffic model of Aw, Rascle and Greenberg. The extended traffic model can be written as a hyperbolic system of balance laws and numerically reproduces the reverse $\lambda$ shape of the fundamental diagram of ...
B. Kerner, D. Helbing, F. Bouchut, F. John, Florian Siebel, J. Greenberg, M. Koshi, P. DuChateau, Wolfram Mauser   +8 more
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Bill It Right: Evaluating Public Charging Station Usage Behavior under the Presence of Different Pricing Policies

World Electric Vehicle Journal
This study investigates for the first time how public charging infrastructure usage differs under the presence of diverse pricing models. About 3 million charging events from different European countries were classified according to five different ...
Markus Fischer, Wibke Michalk, Cornelius Hardt, Klaus Bogenberger   +3 more
doaj   +1 more source

Short-Term Traffic Flow Prediction with Weather Conditions: Based on Deep Learning Algorithms and Data Fusion

Complexity, 2021
Short-term traffic flow prediction is an effective means for intelligent transportation system (ITS) to mitigate traffic congestion. However, traffic flow data with temporal features and periodic characteristics are vulnerable to weather effects, making ...
Yue Hou, Zhiyuan Deng, Hanke Cui
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source