Results 71 to 80 of about 784,260 (281)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Theoretical Comparison of the Effects of Different Traffic Conditions on Urban Road Traffic Noise

Journal of Advanced Transportation, 2018
Road traffic noise is one of the most relevant sources in the environmental noise pollution of the urban areas where dynamics of the traffic flow are much more complicated than uninterrupted traffic flows.
Mohammad Maghrour Zefreh, Adam Torok
doaj   +1 more source

Traffic State Spatial-Temporal Characteristic Analysis and Short-Term Forecasting Based on Manifold Similarity

IEEE Access, 2018
The study on the spatial-temporal characteristics of highway traffic flow is helpful to deeply understand the inherent evolution of highway traffic system and provide a theoretical basis for prediction and control of highway traffic flow.
Qingchao Liu, Yingfeng Cai, Haobin Jiang, Xiaobo Chen, Jian Lu   +4 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

The Application of Cusp Catastrophe Theory to Analyze Road Traffic Potential Characteristics, Considering Headway, with Urban Data

Mathematics
Local data are essential for the analysis of abrupt conditions in traffic flow. In this research, we address the shortcomings of real-time traffic flow detection data, which inadequately represent the density characteristics of vehicular traffic.
Jian Gu, Zining Zeng, Shun Li, Wei Jing, Fuan Huang   +4 more
doaj   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source

Delay Prediction Through Multi-Channel Traffic and Weather Scene Image: A Deep Learning-Based Method

Applied Sciences
Accurate prediction of airport delays under convective weather conditions is essential for effective traffic coordination and improving overall airport efficiency.
Ligang Yuan, Linghua Kong, Haiyan Chen
doaj   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

Traffic Oscillations Mitigation in Vehicle Platoon Using a Car-Following Control Model for Connected and Autonomous Vehicle

Journal of Advanced Transportation, 2019
Traffic oscillations often occur in road traffic, they make traffic flow unstable, unsafe and inefficient. Emerging connected and autonomous vehicle (CAV) technologies are potential solutions to mitigating the traffic oscillations for the advantages that
Zhijun Gao, Jiangfeng Wang, Xi Zhang, Jiakuan Dong, Lei Chen, Xuedong Yan, Wei Zhang   +6 more
doaj   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source