Advanced Science, EarlyView.This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun +8 more
wiley +1 more source
Investment in roads and traffic safety: linked to economic development? A European comparison. [PDF]
Environ Sci Pollut Res Int, 2023 Navarro-Moreno J +2 more
europepmc +1 more source
Boosting Road Safety in Rwanda: Integrating Actuarial Science and Machine Learning for Smarter Traffic Management [PDF]
Jean Claude Mugabo, Ignace Kabano
openalex +1 more source
Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu +14 more
wiley +1 more source
Effects of psychotropic drugs on ocular parameters relevant to traffic safety: A systematic review. [PDF]
Neurosci Biobehav Rev, 2022 Arkell TR +6 more
europepmc +1 more source
The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis
Advanced Science, EarlyView.SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo +5 more
wiley +1 more source
Original and Low-Cost ADS-B System to Fulfill Air Traffic Safety Obligations during High Power LIDAR Operation. [PDF]
Sensors (Basel), 2023 Peyrin F +3 more
europepmc +1 more source
Accuracy assessment of the traffic safety module on two-lane rural roads
, 2023 Romas Girdvainis +4 more
openalex +1 more source
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Advanced Science, EarlyView.Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
Traffic safety knowledge gain of ambulance drivers after simulator-based training. [PDF]
BMC Med Educ, 2022 Prohn MJ, Herbig B.
europepmc +1 more source