Results 51 to 60 of about 495,024 (299)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?
VirusesWorldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells.
Ana Luiza Abdalla +2 more
doaj +1 more source
Global report on trafficking in persons 2012 [PDF]
, 2012 The Global Report on Trafficking in Persons 2012 relays both the data collection and biennial reporting patterns and flows of trafficking in persons at a global, regional and national level, and is carried out in close collaboration with national ...
core
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Help-seeking strategies of victim/survivors of human trafficking involving partner migration [PDF]
, 2014 Drawing on research undertaken to explore the role of partner migration in human trafficking into Australia, this paper presents qualitative data on the help-seeking strategies of victim/survivors of human trafficking and similar exploitative situations ...
Samantha Lyneham +3 more
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Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Sex trafficking in Nepal: context and process [PDF]
, 2004 This study has developed a conceptual framework to provide a clearer understanding of the process and context of sex trafficking from Nepal. Quantitative data were analysed from case records of 202 sex-trafficked women at rehabilitation centres in Nepal.
Simkhada, Padam, Hennink, Monique
core +1 more source
Nature CommunicationsRare mutations in the gene encoding presenilin2 (PSEN2) are known to cause familial Alzheimer’s disease (FAD). Here, we explored how altered PSEN2 expression impacts on the amyloidosis, endolysosomal abnormalities, and synaptic dysfunction observed in ...
Anika Perdok +13 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Threats, Monsters and the ‘Refugee Crisis’
Tilburg Law Review, 2017 Boaventura de Sousa Santos treated Tilburg University to a colorful and rich pallet of topics during his Montesquieu lecture that prompted self-reflection and critical review of the role of law in our western societies.
Conny Rijken
doaj +1 more source