Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Trafficking in Persons: International Dimensions and Foreign Policy Issues for Congress [PDF]
, 2012 [Excerpt] Trafficking in persons, or human trafficking, refers to the subjection of men, women, and children to exploitative conditions that can be tantamount to slavery. Reports suggest that human trafficking is a global phenomenon, victimizing millions
Sun Wyler, Liana
core +6 more sources
Sex Trafficking: Psychoeducational Interventions Relevant to Parent-Child Attachment Relationships [PDF]
, 2020 A brief history of adolescent sex exploitation. Topics include a definition of adolescent sex trafficking exploitation, statistics on sex trafficking exploitation globally and in the US, and risk factors of adolescent sex trafficking exploitation.
Brooks, Jeanne, France, Vivian
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Sex Trafficking and the Attribution of Blame: A Comparison between Vietnamese and American Perception of Sex-trafficked Individuals [PDF]
, 2018 Sex trafficking is one of the most persistent issues in Asian countries and specifically in Vietnam. Hundreds of Vietnamese are trafficked daily across the world, but mainly in Taiwan, Malaysia, South Korea, Laos, China, and Thailand. Sexually trafficked
Nguyen, Tram
core +2 more sources
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2 [PDF]
, 2021 Saigopalakrishna S. Yerneni +3 more
openalex +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Therapy-induced senescence in breast cancer: an overview
Exploration of Targeted Anti-tumor TherapyOutcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire resistance during the course of their ...
Suraj Narayanan Chembukavu +1 more
doaj +1 more source
Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies
Cells, 2018 Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in eukaryotes.
Yoshihiko Kuchitsu, Mitsunori Fukuda
doaj +1 more source