Results 71 to 80 of about 904,971 (330)

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.

open access: yesCell Reports, 2017
STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on and quickly turns off downstream signaling as it translocates from the ER to vesicles.
V. K. Gonugunta   +6 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Threats, Monsters and the ‘Refugee Crisis’

open access: yesTilburg Law Review, 2017
Boaventura de Sousa Santos treated Tilburg University to a colorful and rich pallet of topics during his Montesquieu lecture that prompted self-reflection and critical review of the role of law in our western societies.
Conny Rijken
doaj   +1 more source

Sex Trafficking and the Attribution of Blame: A Comparison between Vietnamese and American Perception of Sex-trafficked Individuals [PDF]

open access: yes, 2018
Sex trafficking is one of the most persistent issues in Asian countries and specifically in Vietnam. Hundreds of Vietnamese are trafficked daily across the world, but mainly in Taiwan, Malaysia, South Korea, Laos, China, and Thailand. Sexually trafficked
Nguyen, Tram
core   +2 more sources

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

open access: yesActa Neuropathologica, 2019
Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness.
K. Burk, R. Pasterkamp
semanticscholar   +1 more source

Sex Trafficking Victims at Their Junction with the Healthcare Setting—A Mixed-Methods Inquiry

open access: yesJournal of Human Trafficking, 2020
U.S.-born citizens are victims of human trafficking typically exploited through sex trafficking. At least some of them interact with healthcare providers during their trafficking experience; yet a majority goes unidentified.
A. C. Richie-Zavaleta   +5 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?

open access: yesViruses
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells.
Ana Luiza Abdalla   +2 more
doaj   +1 more source

Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition

open access: yesSTAR Protocols, 2020
Summary: Lysosomes are dynamic organelles that serve as regulatory hubs in cellular homeostasis. Changes in lysosome morphology, composition, and turnover are typically linked to disease.
Arun Kumar Tharkeshwar   +2 more
doaj   +1 more source

The Rise of Mobile and the Diffusion of Technology-Facilitated Trafficking [PDF]

open access: yes, 2012
In this report, researchers at the USC Annenberg Center on Communication Leadership & Policy (CCLP) reveal how those involved in human trafficking have been quick to adapt to the 21st-century global landscape.
Amber Bissell   +6 more
core  

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