Results 61 to 70 of about 962,136 (301)
Shunting of Passenger Train Units: an Integrated Approach [PDF]
In this paper, we describe a new model for the Train Unit Shunting Problem. This model is capable of solving the matching and parking subproblems in an integrated manner, usually requiring a reasonable amount of computation time for generating acceptable
Schrijver, A. +2 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
French Gratitude Train visitor
, 1950 Visitor to the French Gratitude Train looking at a display case of traditional French dolls. On the wall are posters for the Alsace and Savoie regions of France from the French National Railroad Society.
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Energies, 2020 We designed and analyzed an interior permanent magnet synchronous motor (IPMSM) to prevent irreversible demagnetization of the permanent magnets (PMs). Irreversible demagnetization of NdFeB PMs mainly occurs due to high temperature, which should thus be ...
Jae-Woo Jung +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
French Gratitude Train in Sandusky
, 1950 Photograph of the French Gratitude Train in Sandusky, Ohio, 1950. In 1948 the United States sent a large shipment of food, fuel and clothing to Le Havre, France, to be distributed to needy people in the war-torn country.
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
‘I Need To Learn – Am Learning’: How To Use Inexperience To Craft A Young Adult Voice
Leaf JournalWhat is it that separates the young adult voice from the adult voice in prose? Both might engage in alcohol, sex, crime, war, violence. Both change, grow, love, fail, fall apart.
Elizabeth Train-Brown
doaj +1 more source