Results 81 to 90 of about 2,873,977 (308)
, 2010 We report on the experimental generation of a train of subpicosecond electron bunches. The bunch train generation is accomplished using a beamline capable of exchanging the coordinates between the horizontal and longitudinal degrees of freedom.
A. H. Lumpkin +13 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
On the Similarity of Classical and Bayesian Estimates of Individual Mean Partworths [PDF]
An exciting development in modeling has been the ability to estimate reliable individual-level parameters for choice models. Individual partworths derived from these parameters have been very useful in segmentation, identifying extreme individuals, and ...
Joel Huber, Kenneth Train
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Omitted Product Attributes in Discrete Choice Models [PDF]
We describe two methods for correcting an omitted variables problem in discrete choice models: a fixed effects approach and a control function approach. The control function approach is easier to implement and applicable in situations for which the fixed
Amil Petrin, Kenneth Train
core
Spike train statistics and Gibbs distributions [PDF]
, 2013 This paper is based on a lecture given in the LACONEU summer school, Valparaiso, January 2012. We introduce Gibbs distribution in a general setting, including non stationary dynamics, and present then three examples of such Gibbs distributions, in the ...
Cessac, B., Cofré, R.
core +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Logic circuit detects both present and missing negative pulses in superimposed wave trains [PDF]
, 1967 Pulse divide and determination network provides a logical determination of pulse presence within a data train. The network uses digital logic circuitry to divide positive and negative pulses, to shape the separated pulses, and to determine, by means of ...
Rice, R. E.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Opportunistic Sensing in Train Safety Systems [PDF]
, 2011 Train safety systems are complex and expensive, and changing them requires huge investments. Changes are evolutionary and small. Current developments, like faster - high speed - trains and a higher train density on the railway network, have initiated ...
Bakker, Pascal, Scholten, Hans
core +2 more sources