Results 71 to 80 of about 483,871 (219)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Suspended monorail system dynamics: fundamental and practice

Railway Engineering Science
Urban transportation systems are facing severe challenges due to the rapid growth of the urban population, especially in China. Suspended monorail system (SMS), as a sky rail transportation form, can effectively alleviate urban traffic congestion due to ...
Wanming Zhai, Qinglie He, Yulong Bao, Chengbiao Cai   +3 more
doaj   +1 more source

Design and analysis of multiple bio-inspired aperiodic lattice structures by laser powder bed fusion

Materials & Design
Laser powder bed fusion (LPBF) fabricated lattice structures are widely used as energy absorbers due to their lightweight and porous nature. To develop a bio-inspired lattice structure that enhances energy absorption capacity while achieving controllable
Dongming Li, Tongyuan Sun, Bingzhi Chen, Xu Zhang   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A synergistic arched lattice-honeycomb sandwich metastructure: Balancing impact resistance and thermal management

Materials & Design
Simultaneous enhancement of impact resistance and heat dissipation remains a critical bottleneck in the design of advanced metastructures. Drawing on inspiration from arch bridges, this work proposes a multifunctional sandwich metastructure.
Yanxi Zhao, Leyao Lin, Boyue Lin, Xi Wang, Bingzhi Chen   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Research on intelligent management of air compression refrigeration system in the environmental wind tunnel of high-speed railway trains

High-Speed Railway
The environmental wind tunnel of high-speed railway trains serves as a crucial experimental facility for the research and development of high-speed railway technology. The refrigeration system within the wind tunnel is an important subsystem.
Junjun Zhuang, Meng Liu, Lingfeng Sun, Jun Wang   +3 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Two-Dimensional Porous Structure of V‑Doped NiO with Enhanced Electrochromic Properties

ACS Omega, 2022
Xuhe Zhan, Feiyu Gao, Qianyu Zhuang, Yani Zhang, Jie Dang   +4 more
doaj   +1 more source