Results 91 to 100 of about 34,949 (286)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Stochastic on-time arrival problem in transit networks

, 2018
This article considers the stochastic on-time arrival problem in transit networks where both the travel time and the waiting time for transit services are stochastic.
Blandin, Sebastien, Liu, Yang, Samaranayake, Samitha   +2 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dwell Time Modelling and Optimized Simulations for Crowded Rail Transit Lines Based on Train Capacity

Promet (Zagreb), 2015
Understanding the nature of rail transit dwell time has potential benefits for both the users and the operators. Crowded passenger trains cause longer dwell times and may prevent some passengers from boarding the first available train that arrives ...
Zhibin Jiang, Chao Xie, Tingting Ji, Xiaolei Zou   +3 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Operational measures to maintaining physical distancing at railway stations

International Journal of Transportation Science and Technology
The corona virus disease 2019 (COVID-19) pandemic has increased awareness towards maintaining physical distancing during transportation-related activities.
Keza Harsono, Febri Zukhruf, Idwan Santoso, Sony Sulaksono Wibowo   +3 more
doaj   +1 more source

Minimizing Metro Transfer Waiting Time with AFCS Data Using Simulated Annealing with Parallel Computing

Journal of Advanced Transportation, 2018
Coordinating train arrivals at transfer stations by altering their departure times can reduce transfer waiting time (TWT) and improve level of service. This paper develops a method to optimize train departure times from terminals that minimizes total TWT
Xiaobo Liu, Minghua Huang, Hezhou Qu, Steven Chien   +3 more
doaj   +1 more source

An information-based traffic control in a public conveyance system: reduced clustering and enhanced efficiency

, 2007
A new public conveyance model applicable to buses and trains is proposed in this paper by using stochastic cellular automaton. We have found the optimal density of vehicles, at which the average velocity becomes maximum, significantly depends on the ...
Akiyasu Tomoeda, Andreas Schadschneider, Chowdhury, Chowdhury, Chowdhury, Chowdhury, Debashish Chowdhury, Derrida, Helbing, Ioannides, Jiang, Jiang, Katsuhiro Nishinari, Krbalek, Kunwar, Musha, Nagatani, Nagatani, Nagatani, Nagatani, Newman, Newman, O’Loan, Schadschneider, Zipf   +24 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source