Results 81 to 90 of about 34,949 (286)

Genetic Algorithm-Based Particle Swarm Optimization Approach to Reschedule High-Speed Railway Timetables: A Case Study in China

Journal of Advanced Transportation, 2019
In this study, a mixed integer programming model is proposed to address timetable rescheduling problem under primary delays. The model considers timetable rescheduling strategies such as retiming, reordering, and adjusting stop pattern.
Mingming Wang, Li Wang, Xinyue Xu, Yong Qin, Lingqiao Qin   +4 more
doaj   +1 more source

The Maraca: a tool for minimizing resource conflicts in a non-periodic railway timetable [PDF]

, 2011
While mathematical optimization and operations research receive growing attention in the railway sector, computerized timetabling tools that actually make significant use of optimization remain relatively rare. SICS has developed a prototype tool for non-
Aronsson, Martin, Dahlberg, Hans, Forsgren, Malin, Kreuger, Per   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Design of Traction Calculation and Simulation Platform for Urban Rail Transit

Chengshi guidao jiaotong yanjiu
［Objective］ At the initial stage of urban rail transit projects, it is essential to design a traction calculation simulation platform to accurately evaluate the operational indicators of the signaling system and meet engineering requirements.
GENG Peng, LIU Xia, YUAN Chongyang
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Short Turning Strategy for Train Scheduling Optimization in an Urban Rail Transit Line: The Case of Beijing Subway Line 4

Journal of Advanced Transportation, 2018
In urban rail transit systems, train scheduling plays an important role in improving the transport capacity to alleviate the urban traffic pressure of huge passenger demand and reducing the operation costs for operators.
Miao Zhang, Yihui Wang, Shuai Su, Tao Tang, Bin Ning   +4 more
doaj   +1 more source

Modelling single line train operations [PDF]

, 1995
Scheduling of trains on a single line involves using train priorities for the resolution of conflicts. The mathematical programming model described in the first part of this paper schedules trains over a single line track when the priority of each train ...
Ferreira, Luis, Higgins, Andrew, Kozan, Erhan   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

A dynamic ridesharing dispatch and idle vehicle repositioning strategy with integrated transit transfers

, 2019
We propose a ridesharing strategy with integrated transit in which a private on-demand mobility service operator may drop off a passenger directly door-to-door, commit to dropping them at a transit station or picking up from a transit station, or to both
Chow, Joseph Y. J., Klein, Sylvain, Ma, Tai-Yu, Rasulkhani, Saeid   +3 more
core   +1 more source