Results 71 to 80 of about 1,069 (249)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Dwell Time Modelling and Optimized Simulations for Crowded Rail Transit Lines Based on Train Capacity

Promet (Zagreb), 2015
Understanding the nature of rail transit dwell time has potential benefits for both the users and the operators. Crowded passenger trains cause longer dwell times and may prevent some passengers from boarding the first available train that arrives ...
Zhibin Jiang, Chao Xie, Tingting Ji, Xiaolei Zou   +3 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Operational measures to maintaining physical distancing at railway stations

International Journal of Transportation Science and Technology
The corona virus disease 2019 (COVID-19) pandemic has increased awareness towards maintaining physical distancing during transportation-related activities.
Keza Harsono, Febri Zukhruf, Idwan Santoso, Sony Sulaksono Wibowo   +3 more
doaj   +1 more source

Minimizing Metro Transfer Waiting Time with AFCS Data Using Simulated Annealing with Parallel Computing

Journal of Advanced Transportation, 2018
Coordinating train arrivals at transfer stations by altering their departure times can reduce transfer waiting time (TWT) and improve level of service. This paper develops a method to optimize train departure times from terminals that minimizes total TWT
Xiaobo Liu, Minghua Huang, Hezhou Qu, Steven Chien   +3 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

INCREASING ROBUSTNESS OF TIMETABLES BY DELIBERATE OPERATION OF TRAINS TO SHORTEN HEADWAYS [PDF]

International Journal of Transport Development and Integration, 2016
H. Yabuki, Y. Takatori, M. Koresawa, N. Tomii   +3 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Enhanced Strategy for Optimizing Net Energy Consumption of Railway Systems Using Speed Profile and Variable Headway

Modelling
Energy-efficient operation of railway systems is of great importance for both environmental and economic reasons. Minimizing net energy consumption helps to achieve such energy-efficient operation.
Ahmed Y. Zakariya, Ahmed F. Tayel, Shehab Ahmed   +2 more
doaj   +1 more source

Modeling and optimization of urban rail transit scheduling with adaptive fruit fly optimization algorithm

Open Physics, 2019
Despite the rapid development of urban rail transit in China, there are still some problems in train operation, such as low efficiency and poor punctuality.
Li Jin, Xu Guangyin, Wang Zhengfeng, Wang Zhanwu   +3 more
doaj   +1 more source