Results 61 to 70 of about 34,949 (286)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Simple Model of Rail Infrastructure Capacity and Costs. [PDF]
, 1992 The recent White Paper on "New Opportunities for the Railways" (Cm 2012, 1992) proposes that British Rail's responsibilities for operation and infrastructure will be separated.
Preston, J.M.
core
Dynamic Risk Assessment for Vehicles of Higher Automation Levels by Deep Learning
, 2018 Vehicles of higher automation levels require the creation of situation awareness. One important aspect of this situation awareness is an understanding of the current risk of a driving situation.
Akram, Mohammed Naveed +3 more
core +1 more source
Train Headway Models and Carrying Capacity of Super-Speed Maglev System
JSME International Journal Series C, 2004 Train headway models are established by analyzing the operation of the Transrapid Super-speed Maglev System (TSMS). The variation in the minimum allowable headway for trains of different speeds and consists is studied under various operational constraints.
He, SW, Song, R., Eastham, T.
openaire +3 more sources
International Journal of Rail Transportation, 2021 Rail systems are preferred to find sustainable solutions to traffic problems in cities with high population density.
Lale Özbakır +4 more
openaire +4 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Integrating driving and traffic simulators for the study of railway level crossing safety interventions: a methodology [PDF]
, 2012 Safety at Railway Level Crossings (RLXs) is an important issue within the Australian transport system. Crashes at RLXs involving road vehicles in Australia are estimated to cost $10 million each year.
Ferreira, Luis +4 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Journal of Advanced TransportationHigh-speed railway systems face increasing operational challenges due to rising passenger demand and complex infrastructure constraints. However, traditional space-time network models for train timetabling may lack detailed representation of real-world ...
Angyang Chen +5 more
doaj +1 more source