Results 61 to 70 of about 1,069 (249)

Design of Traction Calculation and Simulation Platform for Urban Rail Transit

Chengshi guidao jiaotong yanjiu
［Objective］ At the initial stage of urban rail transit projects, it is essential to design a traction calculation simulation platform to accurately evaluate the operational indicators of the signaling system and meet engineering requirements.
GENG Peng, LIU Xia, YUAN Chongyang
doaj   +1 more source

Genetic Algorithm-Based Particle Swarm Optimization Approach to Reschedule High-Speed Railway Timetables: A Case Study in China

Journal of Advanced Transportation, 2019
In this study, a mixed integer programming model is proposed to address timetable rescheduling problem under primary delays. The model considers timetable rescheduling strategies such as retiming, reordering, and adjusting stop pattern.
Mingming Wang, Li Wang, Xinyue Xu, Yong Qin, Lingqiao Qin   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Train Headway Calculation and Carrying Capacity Assessment for Moving Block Systems

Kongzhi Yu Xinxi Jishu
With the development of high-traffic-density and mixed-mode urban rail transit systems, train headway has become a restraining factor for transport efficiency and safety.
HUANG Dinghui, LIU Huachao, ZHANG Wenlong   +2 more
doaj  

A Short Turning Strategy for Train Scheduling Optimization in an Urban Rail Transit Line: The Case of Beijing Subway Line 4

Journal of Advanced Transportation, 2018
In urban rail transit systems, train scheduling plays an important role in improving the transport capacity to alleviate the urban traffic pressure of huge passenger demand and reducing the operation costs for operators.
Miao Zhang, Yihui Wang, Shuai Su, Tao Tang, Bin Ning   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Train Headway Models and Carrying Capacity of Super-Speed Maglev System

JSME International Journal Series C, 2004
Train headway models are established by analyzing the operation of the Transrapid Super-speed Maglev System (TSMS). The variation in the minimum allowable headway for trains of different speeds and consists is studied under various operational constraints.
He, SW, Song, R., Eastham, T.
openaire   +3 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source