Results 1 to 10 of about 1,679,257 (365)

Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia

Scientific Reports, 2023
Proxy phenotypes allow for the utilization of genetic data from large population cohorts to analyze late-onset diseases by using parental diagnoses as a proxy for genetic disease risk. Proxy phenotypes based on parental diagnosis status have been used in
Douglas P. Wightman, Jeanne E. Savage, Christiaan A. de Leeuw, Iris E. Jansen, Danielle Posthuma   +4 more
doaj   +1 more source

Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Translational Psychiatry, 2021
Gene-environment interactions (GxE) are often suggested to play an important role in the aetiology of psychiatric phenotypes, yet so far, only a handful of genome-wide environment interaction studies (GWEIS) of psychiatric phenotypes have been conducted.
Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Christiaan A. de Leeuw   +3 more
doaj   +1 more source

Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Communications Biology, 2022
A genome-wide association study on MRI cerebellar volume in the UK Biobank cohort identifies 30 loci with genome-wide significance that might be relevant to brain structure and cognitive function.
Elleke Tissink, Siemon C. de Lange, Jeanne E. Savage, Douglas P. Wightman, Christiaan A. de Leeuw, Kristen M. Kelly, Mats Nagel, Martijn P. van den Heuvel, Danielle Posthuma   +8 more
doaj   +1 more source

Correction to: Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Translational Psychiatry, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01334 ...
Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Christiaan A. de Leeuw   +3 more
doaj   +1 more source

Prompt- and Trait Relation-aware Cross-prompt Essay Trait Scoring [PDF]

, 2023
Automated essay scoring (AES) aims to score essays written for a given prompt, which defines the writing topic. Most existing AES systems assume to grade essays of the same prompt as used in training and assign only a holistic score. However, such settings conflict with real-education situations; pre-graded essays for a particular prompt are lacking ...
arxiv   +1 more source

On the Fourier transform of a quantitative trait: Implications for compressive sensing [PDF]

Journal of Theoretical Biology, Vol. 540, Year 2022, Article ID 110985, ISSN 0022-5193, 2021
This paper explores the genotype-phenotype relationship. It outlines conditions under which the dependence of a quantitative trait on the genome might be predictable, based on measurement of a limited subset of genotypes. It uses the theory of real-valued Boolean functions in a systematic way to translate trait data into the Fourier domain.
arxiv   +1 more source

Open Science principles for accelerating trait-based science across the Tree of Life. [PDF]

, 2020
Synthesizing trait observations and knowledge across the Tree of Life remains a grand challenge for biodiversity science. Species traits are widely used in ecological and evolutionary science, and new data and methods have proliferated rapidly.
Adams, Vanessa M, Alroy, John, Andrew, Samuel C, Ankenbrand, Markus J, Balk, Meghan A, Bland, Lucie M, Boyle, Brad L, Bravo-Avila, Catherine H, Brennan, Ian, Carthey, Alexandra JR, Catullo, Renee, Cavazos, Brittany R, Chown, Steven L, Conde, Dalia A, Enquist, Brian J, Fadrique, Belen, Falster, Daniel S, Feng, Xiao, Gallagher, Rachael V, Gibb, Heloise, Halbritter, Aud H, Hammock, Jennifer, Hogan, J Aaron, Holewa, Hamish, Hope, Michael, Iversen, Colleen M, Jochum, Malte, Kattge, Jens, Kearney, Michael, Keller, Alexander, Mabee, Paula, Madin, Joshua S, Maitner, Brian S, Manning, Peter, McCormack, Luke, Michaletz, Sean T, Park, Daniel S, Pearse, William D, Penone, Caterina, Perez, Timothy M, Pineda-Munoz, Silvia, Poelen, Jorrit H, Ray, Courtenay A, Rossetto, Maurizio, Salguero-Gómez, Roberto, Sauquet, Hervé, Schneider, Florian D, Sparrow, Benjamin, Spasojevic, Marko J, Telford, Richard J, Tobias, Joseph A, Vandvik, Vigdis, Violle, Cyrille, Walls, Ramona, Weiss, Katherine CB, Westoby, Mark, Wright, Ian J   +56 more
core   +4 more sources

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Nature Communications, 2020
Brain volume and intelligence have been previously found to have shared genetic etiology, but the specific common genetic signals have not been identified.
Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei, Jeanne E. Savage, Christiaan A. de Leeuw, Martijn P. van den Heuvel, Sophie van der Sluis, Danielle Posthuma   +8 more
doaj   +1 more source

Genetic distance predicts trait differentiation at the subpopulation but not the individual level in eelgrass, Zostera marina. [PDF]

, 2018
Ecological studies often assume that genetically similar individuals will be more similar in phenotypic traits, such that genetic diversity can serve as a proxy for trait diversity.
Corre V., Harvey P. H., Hughes A. R., Koroleff F., Platt T., R Core Team, Williams S. L.   +6 more
core   +2 more sources

Sex differences in the relationship between sensation seeking, trait emotional intelligence and delinquent behaviour [PDF]

, 2014
Levels of sensation seeking peak in adolescence and there is a well-documented association with delinquency and other risk taking behaviours. The present study investigated the potential moderating effect of trait Emotional Intelligence (EI) on this ...
Bacon, AM, Burak, H, Rann, J
core   +2 more sources