Results 41 to 50 of about 2,335,287 (233)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Research on Intelligent Optimization of Wellbore Trajectory in Complex Formation
Applied SciencesBorehole trajectory optimization is a key issue in oil and gas drilling engineering. The traditional wellbore trajectory design method faces great challenges in optimizing the trajectory length and complexity, and it is difficult to meet the actual ...
Haipeng Gu, Tie Yan, Yang Wu
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Research on Wellbore Trajectory Optimization and Drilling Control Based on the TD3 Algorithm
Applied SciencesIn modern oil and gas exploration and development, wellbore trajectory optimization and control is the key technology to improve drilling efficiency, reduce costs, and ensure safety.
Haipeng Gu +3 more
doaj +1 more source
Strong Optimality for a Bang-Bang Trajectory [PDF]
SIAM Journal on Control and Optimization, 2002 In this paper we give sufficient conditions for a bang-bang regular extremal to be a strong local optimum for a control problem in the Mayer form; strong means that we consider the C 0 topology in the state space.
A. AGRACHEV +2 more
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Utilizing UAVs in Wireless Networks: Advantages, Challenges, Objectives, and Solution Methods
VehiclesUnmanned aerial vehicles (UAVs) have emerged as a promising technology to enhance the performance and functionality of mobile networks. UAVs can act as flying base stations, relays, or users to provide wireless services to ground users or devices ...
Mohammad Javad Sobouti +4 more
doaj +1 more source
Multiconstrained Ascent Trajectory Optimization Using an Improved Particle Swarm Optimization Method
International Journal of Aerospace Engineering, 2021 This paper researches the ascent trajectory optimization problem in view of multiple constraints that effect on the launch vehicle. First, a series of common constraints that effect on the ascent trajectory are formulated for the trajectory optimization ...
Mu Lin +3 more
doaj +1 more source