Results 51 to 60 of about 97,833 (315)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
An inflationary differential evolution algorithm for space trajectory optimization
, 2011 In this paper we define a discrete dynamical system that governs the evolution of a population of agents. From the dynamical system, a variant of Differential Evolution is derived.
Vasile, M. +10 more
core +1 more source
Multiconstrained Ascent Trajectory Optimization Using an Improved Particle Swarm Optimization Method
International Journal of Aerospace Engineering, 2021 This paper researches the ascent trajectory optimization problem in view of multiple constraints that effect on the launch vehicle. First, a series of common constraints that effect on the ascent trajectory are formulated for the trajectory optimization ...
Mu Lin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Utilizing UAVs in Wireless Networks: Advantages, Challenges, Objectives, and Solution Methods
VehiclesUnmanned aerial vehicles (UAVs) have emerged as a promising technology to enhance the performance and functionality of mobile networks. UAVs can act as flying base stations, relays, or users to provide wireless services to ground users or devices ...
Mohammad Javad Sobouti +4 more
doaj +1 more source
Fast Trajectory Generation Method for Midcourse Guidance Based on Convex Optimization
International Journal of Aerospace Engineering, 2022 To generate the midcourse guidance trajectory for intercepting the high-speed and high maneuvering target, which is a strongly nonlinear and strongly constrained problem, a two-stage convex optimization method is proposed to solve the optimal trajectory ...
Jinlin Zhang +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Regularity of the Hamiltonian Along Optimal Trajectories [PDF]
SIAM Journal on Control and Optimization, 2015 This paper concerns state constrained optimal control problems, in which the dynamic constraint takes the form of a differential inclusion. If the differential inclusion does not depend on time, then the Hamiltonian, evaluated along the optimal state trajectory and the co-state trajectory, is independent of time.
Palladino M, Vinter R B
openaire +5 more sources
On the geometry of Zermelo's optimal control trajectories
AUT Journal of Mathematics and Computing, 2022 In the present work, we study the optimal control paths in the Zermelo navigation problem from the geometric and differential equations point of view rather than the optimal control point of view, where the latter has been carried out in our recent work.
Fathi, Zohreh, Bidabad, Behroz
openaire +3 more sources
Automatic Vertical Parking Reference Trajectory Based on Improved Immune Shark Smell Optimization
AlgorithmsParking path optimization is the principal problem of automatic vertical parking (AVP); however, it is difficult to determine a collision avoiding, smooth, and accurate optimized parking path using traditional parking reference trajectory optimization ...
Yan Chen +3 more
doaj +1 more source