Results 71 to 80 of about 97,833 (315)

Reentry Trajectory Optimization of Hypersonic Vehicle Based on Multi-Strategy Improved WOA Optimized Attention-LSTM Network

Aerospace
Trajectory optimization of hypersonic vehicles face challenges from complex aerodynamic environments and multiple constraints, where traditional offline optimization methods struggle to meet real-time requirements.
Encheng Dai, Guangbin Cai, Yonghua Fan, Hui Xu, Hao Wei, Xin Li   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Trajectory Optimization With Implicit Hard Contacts [PDF]

IEEE Robotics and Automation Letters, 2018
ISSN:2377 ...
Jan Carius, René Ranftl, Vladlen Koltun, Marco Hutter 0001   +3 more
openaire   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Trajectory generation for autonomous unmanned aircraft using inverse dynamics [PDF]

, 2010
The problem addressed in this research is the in-flight generation of trajectories for autonomous unmanned aircraft, which requires a method of generating pseudo-optimal trajectories in near-real-time, on-board the aircraft, and without external ...
Drury, R. G.
core  

A Conjugate Gradient-Based BPTT-Like Optimal Control Algorithm With Vehicle Dynamics Control Application [PDF]

, 2010
The paper presents a gradient-based algorithm for optimal control of nonlinear multivariable systems with control and state vectors constraints. The algorithm has a backward-in-time recurrent structure similar to the backpropagation-through-time ...
Kolmanovsky, Ilya V., Novakovic, Branko, Joško Deur, Josip Kasac, Kasac, Josip, Francis Assadian, Branko Novakovic, Deur, Josko, Assadian, Francis, Kolmanovsky, Ilya, Ilya V. Kolmanovsky   +10 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Optimal Trajectory Optimization of 7R Robot for Space Maintenance Operation

IEEE Access
This paper studies the optimal trajectory optimization of a space robot for maintenance operations. A new trajectory planning algorithm is proposed to solve the problems of low maintenance efficiency and poor stationarity of space robots on-orbit ...
Qidong Li, Hehua Ju, Pengfei Xiao, Feifei Chen, Fei Lin   +4 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source