Results 61 to 70 of about 2,377,503 (288)

Trajectory-based global sensitivity analysis in multiscale models

Scientific Reports
This research introduces a novel global sensitivity analysis (GSA) framework for agent-based models (ABMs) that explicitly handles their distinctive features, such as multi-level structure and temporal dynamics.
Valentina Bazyleva, Victoria M. Garibay, Debraj Roy   +2 more
doaj   +1 more source

Trajectory privacy data publishing scheme based on local optimisation and R-tree

Connection Science, 2023
The proliferation of location-based service applications has led to a substantial surge in the amount of life trajectory data produced by mobile devices. And these data frequently contain confidential personal details.
Peiqian Liu, Duoduo Wu, Zihao Shen, Hui Wang   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Trajectory optimization for the Hevelius-lunar microsatellite mission [PDF]

, 2005
In this paper trajectory optimisation for the Hevelius mission is presented. The Hevelius-Lunar Microsatellite Mission - is a multilander mission to the dark side of the Moon, supported by a relay microsatellite, orbiting on a Halo orbit around L2. Three
Colombo, Camilla, Vasile, Massimiliano, Ceriotti, Matteo, Scarì, Ettore   +3 more
core   +3 more sources

Trajectory differential privacy protection mechanism based on prediction and sliding window

Tongxin xuebao, 2020
To address the issues of privacy budget and quality of service in trajectory differential privacy protection,a trajectory differential privacy mechanism integrating prediction disturbance was proposed.Firstly,Markov chain and exponential perturbation ...
Ayong YE, Lingyu MENG, Ziwen ZHAO, Yiqing DIAO, Jiaomei ZHANG   +4 more
doaj   +2 more sources

Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation.

PLoS ONE, 2023
The Elementary Effects method is a global sensitivity analysis approach for identifying (un)important parameters in a model. However, it has almost exclusively been used where inputs are dimensionless and take values on [0, 1].
Rik J L Rutjens, Leah R Band, Matthew D Jones, Markus R Owen   +3 more
doaj   +1 more source

Trajectory generation for road vehicle obstacle avoidance using convex optimization [PDF]

, 2010
This paper presents a method for trajectory generation using convex optimization to find a feasible, obstacle-free path for a road vehicle. Consideration of vehicle rotation is shown to be necessary if the trajectory is to avoid obstacles specified in a ...
H Gollee, Gollee, H., O'Reilly, J., J O'Reilly, G P Bevan, Bevan, G.P., Bevan, Geraint P.; id_orcid   +6 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity

JCI Insight, 2023
In youths with obesity, the gut hormone potentiation of insulin secretion — the incretin effect — is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on β cell function and insulin sensitivity.
Alfonso Galderisi, Domenico Tricò, Jessica Lat, Stephanie Samuels, Ram Weiss, Michelle Van Name, Bridget Pierpont, Nicola Santoro, Sonia Caprio   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source