Results 1 to 10 of about 52,073 (243)
Investigation into the Effects of Tramadol, Citalopram, Tianeptine, and Their Combinations on Rat Brain Tissue [PDF]
BiomedicinesBackground: Tramadol binds to opioid receptors and inhibits norepinephrine and serotonin reuptake, causing serotonin syndrome. Tianeptine stimulates serotonin reuptake and reduces serotonin levels.
Irem Ates +8 more
doaj +2 more sources
A Systematic Review of Laboratory Evidence for the Abuse Potential of Tramadol in Humans
Frontiers in Psychiatry, 2019 Background: Tramadol is an opioid-analgesic that has shown epidemiological evidence of abuse. This review evaluates the evidence for tramadol abuse potential in humans.Methods: A systematic literature search for human abuse liability examinations of ...
Kelly E. Dunn +3 more
doaj +2 more sources
Tramadol—Present and Future [PDF]
Anaesthesia and Intensive Care, 2000 The atypical opioid, tramadol, has recently been introduced into Australia and New Zealand. Tramadol's efficacy in a wide range of acute and chronic pain states, its multi-formulation availability, and its low serious side-effect potential at high doses and in prolonged therapy, combine to bestow on it a user-friendly profile, for short- and long-term
Edward A. Shipton
openalex +4 more sources
Association of Tramadol-Induced Ovarian Damage and Reproductive Dysfunction with Adenosine Triphosphate and the Protective Role of Exogenous ATP Treatment [PDF]
PharmaceuticalsBackground: Tramadol, a weak opioid analgesic agent, is known to induce ovarian damage. Previous studies have held oxidative stress responsible for the adverse effects of tramadol on female reproduction.
Neset Gumusburun +7 more
doaj +2 more sources
Profiles of Drug Substances, Excipients and Related Methodology, 2020 A profile of the analgesic tramadol hydrochloride ((1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride) is provided in this chapter and includes a summary of the physical characteristics known for this drug substance (e.g., UV/vis, IR, NMR, and mass spectra). Details regarding the stability of tramadol hydrochloride in the
R. Smyj, Xiaoping Wang, Feixue Han
semanticscholar +4 more sources
Tramadol Poisoning: A Systematic Review of Studies in Iran
International Journal of Medical Toxicology and Forensic Medicine, 2021 Background: According to statistics, tramadol use is extremely prevalent in Iran. Besides, tramadol overdose is mostly observed in young individuals. Given the significance of this issue and the increasing prevalence of tramadol use in Iran, this study ...
Reza Akhavan +6 more
doaj +1 more source
Biosensors, 2023 In this work, we prepared a novel electrochemical sensor for the detection of tramadol based on a UiO-66-NH2 metal–organic framework (UiO-66-NH2 MOF)/third-generation poly(amidoamine) dendrimer (G3-PAMAM dendrimer) nanocomposite drop-cast onto a glassy ...
Fariba Garkani Nejad +2 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, 2022 The aim of this paper is to assess recent developments in non‐medical tramadol use, tramadol use disorder, illegal procurement and deaths.
A. Roussin +8 more
semanticscholar +1 more source
A review on tramadol toxicity: mechanism of action, clinical presentation, and treatment
Forensic Toxicology, 2021 As an analgesic that acts upon the central nervous system (CNS), tramadol has gained popularity in treating moderate to severe pain. Recently, it has been increasingly reported as a drug of misuse with intentional overdoses or intoxications.
S. Nakhaee +5 more
semanticscholar +1 more source
Drugs, 2021 We conducted a narrative review of the literature to compare the pharmacological, efficacy and safety profiles of tapentadol and tramadol, and to assess the clinical interest of tapentadol in adult patients.
L. Roulet +3 more
semanticscholar +1 more source