Results 91 to 100 of about 30,088 (226)
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 731-744, September 2026.CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit +7 more
wiley +1 more source
Codeine and Metabolite Concentrations in the Breastfed Neonate
Pediatric Anesthesia, Volume 36, Issue 9, Page 1016-1022, September 2026.ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley +1 more source
Pediatric Anesthesia, Volume 36, Issue 9, Page 1132-1142, September 2026.ABSTRACT Introduction Emergence agitation (EA) is a postoperative neurobehavioral complication characterized by a transient disturbance in cognition and perception following anesthesia. Neuroinflammation is thought to play a central role in its pathophysiology.
Nezahat Merve Ata Soylu +6 more
wiley +1 more source
Evaluation of a Wearable Device for Cardiorespiratory Monitoring in Healthy Anaesthetised Cats
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.The OSS was evaluated for heart rate and peripheral oxygen saturation monitoring in healthy anaesthetised cats. A very strong correlation was observed between OSS and a veterinary reference monitor for heart rate measurements and peripheral oxygen saturation values were clinically equivalent within predefined equivalence limits.
Şule Melek +3 more
wiley +1 more source
Anatomia, Histologia, Embryologia, Volume 55, Issue 5, September 2026.ABSTRACT To perform a computed tomography (CT)‐based volumetric assessment of the nasal cavities in domestic cats and to evaluate the relationship between nasal cavity volume and selected morphometric variables. Fifty‐six European cats that underwent CT examination of the head were retrospectively included.
Montel Charles +4 more
wiley +1 more source
Tramadol-induced Mania: A Case Report
Case Reports in Clinical PracticeThis case report describes a rare occurrence of tramadol misuse resulting in a manic episode in a patient without a history of psychiatric disorders. The patient had used tramadol off-label for premature ejaculation.
Sahar Dadfar, Morvarid Ahadi
doaj +1 more source
Technology‐Driven Decision Support for Opioid Tapering: A Scoping Review
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.ABSTRACT Background General practitioners manage most opioid tapering. This process requires time‐consuming, individualised planning accounting for patient preferences, dose options and costs. Consequently, clinicians need tools to support tapering.
Laurits Valberg Hemmingsen +3 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 44, 7 August 2026.SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2624-2635, August 2026.Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins +23 more
wiley +1 more source