Results 91 to 100 of about 37,856 (275)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Miotic action of tramadol is determined by CYP2D6 genotype

, 2006
Polymorphic CYP2D6 is the enzyme that activates the opioid analgesic tramadol by O-demethylation to M1. Our objective was to determine the opioid effects measured by pupillary response to tramadol of CYP2D6 genotyped volunteers in relation to the ...
Kvetina, J, Mikoviny, R, Zima, T, Idle, J R, Nobilis, M, Perlík, F, Slanar, O   +6 more
core  

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Patient-controlled intravenous tramadol versus patient-controlled intravenous hydromorphone for analgesia after secondary cesarean delivery: a randomized controlled trial to compare analgesic, anti-anxiety and anti-depression effects

, 2018
Guangyou Duan,1,* Xiaohang Bao,1,* Guiying Yang,1 Jing Peng,1 Zhuoxi Wu,1 Peng Zhao,1 Zhiyi Zuo,2 Hong Li1 1Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; 2Department of Anesthesiology ...
Yang G, Wu Z, Li H, Zuo Z, Bao X, Zhao P, Duan G, Peng J   +7 more
core  

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

Hemodialysis International, EarlyView.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra, Jordan Fangue‐Nelon, Garima Singh   +2 more
wiley   +1 more source

Tramadol

British Journal of Anaesthesia, 1995
K A, Eggers, I, Power
openaire   +3 more sources

Association of Tramadol-Induced Ovarian Damage and Reproductive Dysfunction with Adenosine Triphosphate and the Protective Role of Exogenous ATP Treatment

Pharmaceuticals
Background: Tramadol, a weak opioid analgesic agent, is known to induce ovarian damage. Previous studies have held oxidative stress responsible for the adverse effects of tramadol on female reproduction.
Neset Gumusburun, Ilhan Bahri Delibasi, Seval Bulut, Halis Suleyman, Betul Kalkan Yilmaz, Taha Abdulkadir Coban, Ali Sefa Mendil, Zeynep Suleyman   +7 more
doaj   +1 more source

Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment

, 2015
Xiao Zhou, Ji Liu Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China Abstract: This study developed a revised high-performance liquid chromatography fluorescence method ...
Liu J, Zhou X
core  

Tramadol and delirium [PDF]

Anaesthesia, 2015
N, Rughooputh, R, Griffiths
openaire   +2 more sources

Antagonistic effects of ondansetron and tramadol? A randomized placebo and active drug controlled study

, 2010
Opposing effects of ondansetron and tramadol on the serotonin pathway have been suggested which possibly increase tramadol consumption and emesis when co-administered.
Neele I. Rauers, Barann, Martin, Frank Stüber, Fimmers, Rolf, Martin Barann, Ulrike M. Stamer, Lee, Eun-Hae, Stamer, Ulrike M, Stüber, Frank, Musshoff, Frank, Rolf Fimmers, Frank Musshoff, Rauers, Neele I, Eun-Hae Lee   +13 more
core   +1 more source