Results 51 to 60 of about 94,263 (328)

Toxicology of tramadol following chronic exposure based on metabolomics of the cerebrum in mice

Scientific Reports, 2020
Tramadol is an opioid used as an analgesic for treating moderate or severe pain. The long-term use of tramadol can induce several adverse effects. The toxicological mechanism of tramadol abuse is unclear.
W. Xia, Guojie Liu, Ziyi Shao, E. Xu, Huiya Yuan, Junting Liu, Lina Gao   +6 more
semanticscholar   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

Tramadol

, 2006
europepmc   +2 more sources

Safety Events Associated with Tramadol Use Among Older Adults with Osteoarthritis

Population health management, 2020
Tramadol is a low-level opioid increasingly recommended to treat moderate-to-severe acute and chronic pain. Although characterized as having fewer opioid-related adverse events, the longer term safety of tramadol use among older adults has not been ...
S. Musich, Shaohung S. Wang, J. Schaeffer, L. Slindee, S. Kraemer, C. Yeh   +5 more
semanticscholar   +1 more source

A comparative study of postmortem distribution and postmortem diffusion of tramadol in rabbits

Scientific Reports, 2023
In recent years, the cases of tramadol intoxication have become more frequent in many countries. However, most of the previous studies have been based on cases of tramadol intoxication, and the detailed information on the differences between postmortem ...
Hongliang Su, Lingxiao Wang, Amin Wurita, Chao Zhang, Miaomiao Wu, Bin Li, Weifen Niu, Youmei Wang, Zhiwen Wei, Keming Yun   +9 more
doaj   +1 more source

Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

Frontiers in Pharmacology, 2021
Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in ...
Nenad Neskovic, Nenad Neskovic, Dario Mandic, Dario Mandic, Saska Marczi, Saska Marczi, Sonja Skiljic, Sonja Skiljic, Gordana Kristek, Gordana Kristek, Hrvoje Vinkovic, Hrvoje Vinkovic, Boris Mraovic, Zeljko Debeljak, Zeljko Debeljak, Slavica Kvolik, Slavica Kvolik   +16 more
doaj   +1 more source

Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy

Scientific Reports
Despite advancements in trauma care, uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) remain the leading causes of preventable deaths after trauma.
Qingsong Chen, Tao Li, Tao Zhang, Yue Zhou, Weifeng Huang, Hui Li, Li Shi, Jianxiao Li, Qi Zhang, Man Ma, Pan Wang, Hui Hu, Gongbin Wei, Jiangxia Xiang, Yuan Cheng, Jun Yang, Guangbin Huang, Yongming Li, Dingyuan Du   +18 more
doaj   +1 more source

The acute effects of different doses of tramadol on neuronal activity of medial prefrontal cortex in rats

Advanced Biomedical Research, 2022
Background: Tramadol is an opioid analgesic with monoamine reuptake inhibitory effects. Although tramadol has been widely used to control pain, there is controversy about the risk of abuse.
Neda Hasanpour Razmanjani, Parham Reisi
doaj   +1 more source

Moringa oleifera leaves extract modulates toxicity, sperms alterations, oxidative stress, and testicular damage induced by tramadol in male rats.

Toxicological Research, 2020
Tramadol is a synthetic opioid analgesic used for moderate-to-severe pain structurally related to codeine and morphine, where their analgesic mechanism is a result of opioid and non-opioid mechanisms.
Haitham Hassen Abd, Harith Abdulrahman Ahmed, T. Mutar   +2 more
semanticscholar   +1 more source

Physician Referral Patterns to Physical Therapists for Managing Knee Osteoarthritis: A Retrospective Analysis of Electronic Health Records From an Integrated Health System

Arthritis Care &Research, EarlyView.
Objective This study aims to describe the frequency and timing of physician referrals to physical therapists (PTs) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja, Joel M. Stevans, Gustavo J. Almeida, Clair Smith, Janet K. Freburger   +4 more
wiley   +1 more source