Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis. [PDF]
PLoS ONE, 2015 Tramadol is thought to modulate synaptic transmissions in the spinal dorsal horn mainly by activating µ-opioid receptors and by inhibiting the reuptake of monoamines in the CNS. However, the precise mode of modulation remains unclear.
Hiroyuki Yamasaki +4 more
doaj +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Silymarin extract modulates toxicity, injury, oxidative stress, and PCNA alternations induced by tramadol in rat liver [PDF]
Journal of Bioscience and Applied Research, 2017 Tramadol is a synthetic opioid analgesic commonly prescribed for moderate to severe pain. This study was designed to evaluate the effects of silymarin supplementation on Tramadol induce injury, oxidative stress, and PCNA expression alterations on the ...
Nadhom Khalaf
doaj +1 more source
Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac [PDF]
, 2010 Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action.
Adappa, Karunakara +7 more
core +1 more source
Axial Multicentric Osteosarcoma in an English Cocker Spaniel [PDF]
, 2016 No abstract ...
Carvalho, S +6 more
core +3 more sources
Pharmacogenomic testing and its future in community pharmacy [PDF]
, 2020 Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source
BiomedicinesBackground: Tramadol binds to opioid receptors and inhibits norepinephrine and serotonin reuptake, causing serotonin syndrome. Tianeptine stimulates serotonin reuptake and reduces serotonin levels.
Irem Ates +8 more
doaj +1 more source
PENGARUH PEMBERIAN ANALGESIK KOMBINASI PARASETAMOL DAN TRAMADOL TERHADAP KADAR SERUM GLUTAMAT PIRUVAT TRANSAMINASE TIKUS WISTAR [PDF]
, 2017 Latar Belakang : Kombinasi parasetamol dan tramadol merupakan analgesik kombinasi yang ideal dan efektif dalam menangani nyeri derajat sedang sampai berat. Keduanya bekerja pada mekanisme berbeda dalam penangan nyeri.
Nugroho, Taufik Eko +1 more
core
CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids [PDF]
, 2017 Purpose When codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief.
Broome, Marion E. +6 more
core +2 more sources