Results 81 to 90 of about 52,129 (297)

Randomized Double Blind Comparison of Prophylactic Tramadol and Tramadol Plus Ketamine for Prevention of Shivering after Spinal Anesthesia in Lower Segment Caesarian Section

Journal of the Dow University of Health Sciences
Objective: To assess the effectiveness of prophylactic intravenous tramadol alone versus a combination of tramadol and ketamine in preventing shivering during spinal anesthesia for lower segment caesarean section.
Muhammad Arif, Zeeshan Mirza, Haider Abbas Mandviwala, Sajid Saif, Rabeea Khan, Muhammad Hassam   +5 more
doaj   +1 more source

Impact of First‐of‐Its‐Kind Patient‐Facing Pharmacogenetics Tool on Dosing Decisions and Treatment Outcomes

Clinical Pharmacology &Therapeutics, EarlyView.
Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient‐facing portal that delivers multi‐gene PGx results (CYP2D6, UGT1A1, DPYD) through ...
Youngwoo Cho, Sami Elahi, Matthew M. Jack, John Campbell, Emily Smith, Randall W. Knoebel, David George, Larry House, Kiang‐Teck J. Yeo, Theodore Karrison, Samuel L. Volchenboum, David O. Meltzer, Russell Z. Szmulewitz, Everett E. Vokes, Mark J. Ratain, Peter H. O'Donnell   +15 more
wiley   +1 more source

Inibição da corrente de cálcio tipo L por tramadol e enantiômeros em miócitos cardíacos de ratos Inhibition of L-type calcium current by tramadol and enantiomers in cardiac myocytes from rats

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: O tramadol é um analgésico de ação central cujo mecanismo de ação envolve a ativação de um receptor opioide. Anteriormente, mostramos que o tramadol e seus enantiômeros apresentavam um efeito inotrópico negativo sobre o músculo papilar no ...
Emiliano Medei, Juliana M. Raimundo, José Hamilton M. Nascimento, Margarete M. Trachez, Roberto T. Sudo, Gisele Zapata-Sudo   +5 more
doaj  

Comparison of tramadol and tramadol/droperidol mixture for patient-controlled analgesia [PDF]

Canadian Journal of Anaesthesia, 1997
To compare the analgesic efficacy and side effects of tramadol vs tramadol and droperidol for post-operative patient-controlled analgesia (PCA).Randomised, double-blind study. Thirty-four patients undergoing elective colorectal or head and neck surgery were allocated to Group 1 (n = 18, PCA bolus 10 mg tramadol) or Group 2 (n = 16, PCA bolus 10 mg ...
Ng, KFJ, Tsui, SL, Yang, JCS, Ho, ETF
openaire   +4 more sources

Pharmacogenetic Implementation Studies—Lessons Learned From the PREPARE Study

Clinical Pharmacology &Therapeutics, EarlyView.
The Ubiquitous Pharmacogenomics consortium (www.upgx.eu) has recently completed and published the Preemptive Pharmacogenomic Testing for Preventing Adverse Drug Reactions (PREPARE) study on the implementation of panel‐based pharmacogenetic testing. PREPARE has provided interesting lessons for the design, execution, and interpretation of future clinical
Henk‐Jan Guchelaar, Cathelijne H. van der Wouden, Lisanne E. N. Manson, Heshu Abdullah‐Koolmees, Kathrin Blagec, Tanja Blagus, Stefan Böhringer, Erika Cecchin, Ka‐Chun Cheung, Vera H. M. Deneer, Siv Jonsson, Candace Joefield‐Roka, Katja S. Just, Mats O. Karlsson, Lidija Konta, Rudolf Koopmann, Marjolein Kriek, Thorsten Lehr, Christina Mitropoulou, Victoria Rollinson, Rossana Roncato, Matthias Samwald, Elke Schaeffeler, Maria Skokou, Matthias Schwab, Daniela Steinberger, Julia C. Stingl, Roman Tremmel, Richard M. Turner, Mandy H. van Rhenen, Cristina L. Dávila‐Fajardo, Vita Dolžan, George P. Patrinos, Munir Pirmohamed, Gere Sunder‐Plassmann, Giuseppe Toffoli, Jesse J. Swen, Ubiquitous Pharmacogenomics Consortium   +37 more
wiley   +1 more source

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, EarlyView.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Anthraquinone Sulfonates as Water‐Soluble Photocatalysts: Synthetic Applications and Perspectives

ChemPhotoChem, EarlyView.
The development of photochemistry in water is rapidly advancing, and the demand for water‐soluble photocatalysts is increasing. Accordingly, anthraquinone sulfonates are interesting options for the activation of organic molecules through H‐atom transfer, proton‐coupled electron transfer, or the generation of reactive oxygen species.
Daniel Kolb, Andrey Fedulin, Burkhard König   +2 more
wiley   +1 more source

Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MSn System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma

Drug Testing and Analysis, EarlyView.
Simultaneous qualitative and quantitative analysis of 62 drugs and seven active metabolites in human blood plasma by automated liquid chromatography linear ion trap mass spectrometry. ABSTRACT Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of ...
Selina Hemmer, Maximilian Ninnig, Lea Wagmann, Sascha K. Manier, Markus R. Meyer   +4 more
wiley   +1 more source

PENGARUH PEMBERIAN ANALGESIK KOMBINASI PARASETAMOL DAN TRAMADOL TERHADAP KADAR KREATININ SERUM TIKUS WISTAR

Jurnal Kedokteran Diponegoro, 2016
Latar Belakang : Kombinasi parasetamol dan tramadol merupakan analgesik kombinasi yang ideal dan efektif dalam menangani nyeri derajat sedang sampai berat.
Gianita Puspita Dewi, Taufik Eko Nugroho
doaj   +1 more source

Workplace Drug Testing—Prevalence of Positive Test Results, Most Common Substances, and Importance of Medical Review

Drug Testing and Analysis, EarlyView.
Among 23,900 urine and oral fluid drug tests from Swedish workplaces, 4.6% tested positive for controlled substances. Cannabis, amphetamine, cocaine and benzodiazepines were most common. Many samples containing opiates, amphetamine or benzodiazepines were MRO verified as being due to medical prescriptions, while cannabis or cocaine were almost entirely
Anders Helander, Fredrik Sparring
wiley   +1 more source