Results 1 to 10 of about 5,005,447 (264)

Prehospital tranexamic acid for trauma victims

Journal of Intensive Care, 2023
The public enquiry into the mass casualty incident at the Manchester Arena in the UK in which 23 people died and over 1000 were injured, identified the need for timely intramuscular administration of tranexamic acid to trauma patients.
Kazuhiko Omori, Ian Roberts
doaj   +2 more sources

Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo-controlled trial

Stroke and Vascular Neurology, 2021
Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral ...
Liping Liu, Yuehua Pu, Yongjun Wang, Yan Wang, Xingquan Zhao, Hongqiu Gu, Qi Zhou, Yibin Cao, Wenzhi Wang, Dacheng Liu, Jingyi Liu, Haixin Sun, Zhonghua Yang, Ximing Nie, Miao Wen, Shengjun Sun, Ying Tan, Lina Zheng, Jiahui Zhao, Haomeng Zhu, Yunpeng Zhang, Lijin Yi   +21 more
doaj   +2 more sources

Tranexamic acid: Beyond antifibrinolysis

Transfusion, 2022
Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma patients and cardiovascular, orthopedic, and gynecological surgical patients. TXA binds plasminogen and prevents its maturation to the fibrinolytic enzyme plasmin.
I. Prudovsky, Doreen Kacer, V. Zucco, M. Palmeri, C. Falank, Robert Kramer, D. Carter, J. Rappold   +7 more
semanticscholar   +3 more sources

Topical tranexamic acid prevents scar tissue formation following craniectomy in a rat model [PDF]

European Journal of Medical Research
Background We carried out a study to assess the efficacy of tranexamic acid in preventing scar tissue in the craniectomy area in rats. Method Our study consisted of control and tranexamic acid groups with 10 subjects each.
Ömer Şahin, Tuncer Taşcıoğlu, Ayşegül Fırat, Hüseyin Selçuk Sürücü, Muzaffer Çaydere   +4 more
doaj   +2 more sources

Efficacy of oral Tranexamic Acid in reducing blood loss during primary total hip arthroplasty: A comparative study

Ibom Medical Journal, 2023
Background: Perioperative blood loss is a major concern for patients undergoing total hip arthroplasty. Intravenous Tranexamic acid is commonly used to reduce blood loss and need for blood transfusion following total hip replacement. Recent studies have
Essien UE, Inyang UC, Itakpe SE, Lawal WO, Dim EM, Usendiah IB   +5 more
doaj   +1 more source

Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery.

New England Journal of Medicine, 2023
BACKGROUND Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.
L. Pacheco, R. Clifton, G. Saade, Steven J. Weiner, S. Parry, J. Thorp, M. Longo, A. Salazar, W. Dalton, Alan T N Tita, C. Gyamfi‐Bannerman, S. Chauhan, T. Metz, K. Rood, D. Rouse, J. Bailit, W. Grobman, H. Simhan, G. Macones   +18 more
semanticscholar   +1 more source

Tranexamic acid for haemostasis and beyond: does dose matter?

Thrombosis Journal, 2023
Tranexamic acid (TXA) is a widely used antifibrinolytic agent that has been used since the 1960’s to reduce blood loss in various conditions. TXA is a lysine analogue that competes for the lysine binding sites in plasminogen and tissue-type plasminogen ...
Tammy Lam, R. Medcalf, Geoffrey C. Cloud, Paul S Myles, Charithani B. Keragala   +4 more
semanticscholar   +1 more source

Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery: a systematic review, meta-analysis and trial sequential analysis.

Anaesthesia, 2023
Tranexamic acid is an antifibrinolytic drug that is widely used during surgery, but there are concerns about its thromboembolic effects. We aimed to investigate the effect of prophylactic intravenous tranexamic acid on thromboembolic outcomes in patients
S. E. H. Tsan, N. L. Viknaswaran, C. C. Cheong, S. Cheah, K. Ng, S. Mong, C. Y. Wang   +6 more
semanticscholar   +1 more source

Effect of tranexamic acid administration on intraoperative blood loss during peritonectomy: a single-center retrospective observational study

JA Clinical Reports, 2023
Background The efficacy of tranexamic acid in elective major invasive abdominal surgeries has not yet been established. We investigated the effect of tranexamic acid administration on intraoperative blood loss during peritoneal resection of ...
Daiki Shirasu, Masahiko Tsuchiya, Noriaki Oomae, Wataru Shirasaka, Tatsuhiko Iino, Daisuke Hirano, Makoto Satani   +6 more
doaj   +1 more source

Tranexamic acid-induced focal convulsions after spinal surgery: a rare case report and literature review on side effects of accidental spinal administration of tranexamic acid

EFORT Open Reviews, 2023
Convulsions are a neurological illness that has complexity. In clinical treatment, drug-induced convulsions appear from time to time. Drug-induced convulsions often begin as isolated acute seizures but may progress to persistent seizures. In orthopedics,
Hua Luo, Chaojun Shen, Tongyou Qu, Lin Chen, Yue Sun, Yu Ren   +5 more
doaj   +1 more source