Results 51 to 60 of about 5,067,781 (348)

Tranexamic Acid Update in Trauma [PDF]

Critical Care Clinics, 2017
Following results from the CRASH-2 trial, tranexamic acid (TXA) gained considerable interest for the treatment of hemorrhage in trauma patients. Although TXA is effective at reducing mortality in patients presenting within 3 hours of injury, optimal dosing, timing of administration, mechanism, and pharmacokinetics require further elucidation.
Grant V. Bochicchio, Ricardo J. Ramirez, Philip C. Spinella   +2 more
openaire   +3 more sources

Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial.

JAMA Surgery, 2020
Importance In-hospital administration of tranexamic acid after injury improves outcomes in patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic use of tranexamic acid in the prehospital phase of care are lacking for
Francis X Guyette, Joshua B. Brown, M. Zenati, Barbara J. Early‐Young, Peter W. Adams, B. Eastridge, R. Nirula, G. Vercruysse, T. O'keeffe, B. Joseph, L. Alarcon, C. Callaway, B. Zuckerbraun, M. Neal, R. Forsythe, M. Rosengart, T. Billiar, D. Yealy, A. Peitzman, J. Sperry   +19 more
semanticscholar   +1 more source

Abdominal trauma in dogs 2. management [PDF]

, 2018
Trauma represents a big challenge for emergency doctors both in human and veterinary medicine. There have been great advancements in trauma medicine in people and these often provide an inspiration for veterinary surgeons.
Cortellini, S, Humm, K R
core   +1 more source

Comparing the Efficacy of Patelet-rich Plasma (PRP) versus Tranexamic Acid (4mg/mL) as Intradermal Treatments of Melasma.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2021
OBJECTIVE To compare the efficacy of intradermal platelet-rich-plasma vs. intradermal tranexamic acid in treatment of melasma. STUDY DESIGN Non-randomised controlled trial.
M. Mumtaz, Tahir Hassan Chandio, Mohammad Shahzad, Nazia Hanif, Sarah Anwar, Saira Rafique   +5 more
semanticscholar   +1 more source

Validation of the BATT score for prehospital risk stratification of traumatic haemorrhagic death: usefulness for tranexamic acid treatment criteria

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2021
Background Tranexamic acid reduces surgical blood loss and reduces deaths from bleeding in trauma patients. Tranexamic acid must be given urgently, preferably by paramedics at the scene of the injury or in the ambulance.
Francois-Xavier Ageron, Timothy J. Coats, Vincent Darioli, Ian Roberts   +3 more
doaj   +1 more source

The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial. [PDF]

, 2018
BACKGROUND: In severe post-partum haemorrhage, death can occur within hours of bleeding onset so interventions to control the bleeding must be given immediately.
A Godier, A Pilbrant, Amy Brenner, BE Yee, Bukola Fawole, DJ Fletcher, H Shakur, H Shakur, Haleema Shakur-Still, I Roberts, Ian Roberts, K Ker, KJ Rothman, L Andersson, L Andersson, MA Hernán, R Fears, Rizwana Chaudhri, Sabaratnam Arulkumaran, WOMAN Trial Collaborators   +19 more
core   +2 more sources

Tranexamic acid: a clinical review

Anestezjologia Intensywna Terapia, 2015
Blood loss and subsequent transfusions are associated with major morbidity and mortality. The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic surgery, liver surgery and solid organ transplantation, obstetrics and gynecology, neurosurgery and non-surgical diseases.
Angela Jerath, Marcin Wąsowicz, William C. K. Ng   +2 more
openaire   +2 more sources

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Nanomaterials
Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery.
Changfa Huang, Menglong Wang, Siyou Yu, Dengguang Yu, S. A. Bligh   +4 more
semanticscholar   +1 more source

Tranexamic acid therapy in pediatric cardiac surgery:a single center study [PDF]

, 2012
Background: We conducted a retrospective study of cyanotic and acyanotic patients undergoing cardiopulmonary bypass to determine the effect of tranexamic acid on blood loss and blood products administered during the operation in pediatric cardiac surgery.
Cioffi S, Giordano R, MANNACIO, VITO ANTONIO, Mucerino M, PALMA, GAETANO, Palumbo S, Poli V, Russolillo V, VOSA, CARLO   +8 more
core   +1 more source

Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT.

Health Technology Assessment, 2021
BACKGROUND Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death.
I. Roberts, H. Shakur-Still, A. Aeron-Thomas, D. Beaumont, A. Belli, A. Brenner, Madeleine Cargill, R. Chaudhri, N. Douglas, Lauren Frimley, Catherine Gilliam, A. Geer, Z. Jamal, R. Jooma, Raoul Mansukhani, A. Miners, J. Pott, D. Prowse, T. Shokunbi, Jack Williams   +19 more
semanticscholar   +1 more source