Results 61 to 70 of about 5,023,654 (293)

Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened.
Lucia Rugeri, Yelena Fruchou, Caroline Brodbeck, Marianne Bastien, Amandine Lioux, Giulia Gouy, Marion Cortet, Gil Dubernard, Yesim Dargaud   +8 more
wiley   +1 more source

Topical tranexamic acid improves the permeability barrier in rosacea

Dermatologica Sinica, 2015
Objective: To evaluate the influence of tranexamic acid on epidermal permeability barrier function in rosacea and its potential mechanisms. Methods: A randomized, vehicle controlled, split-face study was performed on 30 rosacea patients.
Shaomin Zhong, Nan Sun, Huixian Liu, Yueqing Niu, Can Chen, Yan Wu   +5 more
doaj   +1 more source

Evaluating Tranexamic Acid Dosing Strategies for Postpartum Hemorrhage: A Population Pharmacokinetic Approach in Pregnant Individuals

The Journal of Clinical Pharmacology, EarlyView.
Abstract Tranexamic acid (TXA) is used for the treatment and occasionally prevention of postpartum hemorrhage (PPH); however, questions still remain regarding dosing regimen optimization. This study evaluated TXA pharmacokinetic (PK) data from four clinical trials (NCT: 04274335, 03287336, 00872469, and 02797119) conducted in pregnant participants ...
Allison Dunn, Mina Felfeli, Sebastian M. Seifert, Sixtine Gilliot, Anne‐Sophie Ducloy‐Bouthors, Haleem Shakur‐Still, Amber Geer, Stanislas Grassin‐Delyle, Naomi L. Luban, Johannes N. van den Anker, Jogarao V. S. Gobburu, Ian Roberts, Homa K. Ahmadzia   +12 more
wiley   +1 more source

Tranexamic acid reduces intraoperative occult blood loss and tourniquet time in obese knee osteoarthritis patients undergoing total knee arthroplasty: a prospective cohort study

Therapeutics and Clinical Risk Management, 2018
Yutong Meng,1,* Zhirui Li,1,2,* Ke Gong,1 Xiao An,2 Jiyuan Dong,1 Peifu Tang1 1Department of Orthopedics, Chinese PLA General Hospital, Beijing, China; 2Department of Orthopedics, Chinese PLA General Hospital Hainan Branch, Sanya, China *These authors ...
Meng Y, Li Z, Gong K, An X, Dong J, Tang P   +5 more
doaj  

Tranexamic Acid Inhibits Angiogenesis and Melanogenesis in Vitro by Targeting VEGF Receptors

International Journal of Medical Sciences, 2020
Melasma is a common but complex skin condition concerning cosmetic problems. Tranexamic acid (TA) has been proved to be effective in treatment of melasma with still unclear mechanisms. Here, we show that VEGF165 enhanced the expression of VEGF receptors (
Jian-wei Zhu, Ya-jie Ni, Xiao-Yun Tong, Xia Guo, Xiao-Ping Wu, Zhongfa Lu   +5 more
semanticscholar   +1 more source

The Effectiveness of Intravenous Tranexamic Acid on Blood Loss and Surgical Time During Endoscopic Sinus Surgery: A Systematic Review

Philippine Journal of Otolaryngology Head and Neck Surgery, 2018
Objective: To review the effectiveness of intravenous tranexamic acid in reduction of blood loss, surgical time and field visualization among patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS).
Jona Minette E. Ligon, Natividad A. Almazan   +1 more
doaj   +1 more source

The effect of tranexamic acid on blood loss and maternal outcome in the treatment of persistent postpartum hemorrhage: A nationwide retrospective cohort study. [PDF]

PLoS ONE, 2017
Recent results show a protective effect of tranexamic acid on death due to bleeding in patients with postpartum hemorrhage in low- and middle-resource countries. We quantify the association between early administration of tranexamic acid compared to late
Ada Gillissen, Dacia D C A Henriquez, Thomas van den Akker, Camila Caram-Deelder, Merlijn Wind, Joost J Zwart, Jos van Roosmalen, Jeroen Eikenboom, Kitty W M Bloemenkamp, Johanna G van der Bom, TeMpOH-1 study group   +10 more
doaj   +1 more source

Hereditary hypofibrinogenemia: A rare cause of chronic liver disease

JPGN Reports, EarlyView.
Abstract Hypofibrinogenemia is characterized by low levels of fibrinogen with patients commonly presenting asymptomatically. This report discusses a case of hereditary hypofibrinogenemia manifesting as chronic liver disease in a 2‐year‐old male who was evaluated for elevated liver enzymes and skin/soft tissue bleeding.
Hannah Caringal, Nolan Maloney, Khyati Mehta, Akshat Jain, Kalyan Parashette   +4 more
wiley   +1 more source

The use of ROTEM in Detection of Coagulopathy and Altered Hemostasis in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Patients undergoing Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are at risk of coagulopathy. This study aims to evaluate the potential role of rotational thromboelastometry (ROTEM) in detecting alterations in coagulation during and after CRS/HIPEC.
Abdullah Mashat, Kadhim Taqi, Marina Parapini, Julia Chen, Jacqueline Trudeau, Jason Wilson, Trevor D. Hamilton, Andrea J MacNeill   +7 more
wiley   +1 more source

Effect of tranexamic acid on mortality in patients with haemoptysis: a nationwide study

Critical Care, 2019
Background Although tranexamic acid is widely used in patients with haemoptysis, whether it improves mortality has not been well investigated. The aim of this study was to evaluate the effect of tranexamic acid on in-hospital mortality among patients ...
Takahiro Kinoshita, Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hiroshi Ogura, Hideo Yasunaga   +5 more
doaj   +1 more source