Results 81 to 90 of about 24,428 (246)

Modeling Hereditary Angioedema With Personalized EPSC‐Derived Hepatocytes: A CRISPR‐Validated Platform for Mutation‐Specific Mechanisms and Therapeutic Innovation

Allergy, EarlyView.
Patient‐derived expanded potential stem cell (EPSC) hepatocytes reveal that pathogenic SERPING1 variants cause distinct cellular defects in hereditary angioedema. While most mutations reduce SERPING1 transcription and C1‐INH secretion, a large deletion induces intracellular C1‐INH retention.
Xueyan Liu, Yuxin Wang, Jane C. Y. Wong, Xiang Zhang, Cuixi Wu, Pengyu Chen, Yunzhi Yang, Pentao Liu, Chak Sing Lau, Matthew Cook, Philip Hei Li   +10 more
wiley   +1 more source

The Effect of Intravenous Tranexamic Acid on Postoperative Ecchymoses after Upper Blepharoplasty

Plastic and Reconstructive Surgery, Global Open
Background:. Tranexamic acid has been increasingly used in facial plastic surgery to improve perioperative hemostasis. While subcutaneous tranexamic acid has been found to not significantly decrease postoperative ecchymoses following upper blepharoplasty,
Ashtyn Z. Vogt, MD, Pouriska B. Kivanany, MD, PhD, MS, Matthew A. De Niear, MD, PhD, Ivan M. Vrcek, MD, Natalie A. Homer, MD, FACS   +4 more
doaj   +1 more source

The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial

BACKGROUND AND OBJECTIVES: An important proportion of patients with spontaneous intracerebral hemorrhage (ICH) undergo neurosurgical intervention to reduce mass effect from large hematomas and control the complications of bleeding, including hematoma ...
Woodhouse, Lisa J., Roffe, Christine, Peters, Nils, Bath, Philip M., Ali, Azlinawati, Christensen, Hanne, Bereczki, Dániel, England, Timothy J., Ozturk, Serefnur, Werring, David, Robinson, Thompson, Hollingworth, Milo, Sprigg, Nikola, Dineen, Robert A., Egea-Guerrero, Juan José, Ciccone, Alfonso, Członkowska, Anna, Law, Zhe K., Krishnan, Kailash   +18 more
core   +1 more source

Berotralstat and Health‐Related Quality of Life in Hereditary Angioedema: Pooled Analysis of the APeX‐2 and APeX‐J Trials

Clinical &Experimental Allergy, EarlyView.
Pooled analysis of the phase 3 APeX‐2 and APeX‐J trials evaluated the impact of berotralstat 150 mg on health‐related quality of life in patients with hereditary angioedema using the Angioedema Quality of Life (AE‐QoL) questionnaire. Berotralstat significantly improved AE‐QoL total and domain scores for daily functioning and fears/shame versus placebo ...
Teresa Caballero, Sorena Kiani‐Alikhan, Douglas T. Johnston, Aolin Wang, Lorena Lopez‐Gonzalez, Zheng‐Yi Zhou, Fan Yang, Hannah H. Kim, Sandra Nestler‐Parr, Dianne Tomita, Patrick Gillard, Tamar Kinaciyan   +11 more
wiley   +1 more source

Effects of Tranexamic Acid on Intraoperative Bleeding and Surgical Field Visualization During Middle Ear Surgery: A Narrative Review

Tranexamic acid is an antifibrinolytic agent widely used in several surgical procedures to reduce intraoperative bleeding. Intraoperative bleeding is a crucial problem for the ear surgeon, as it prevents good visualization of the surgical field.
Morgane Marc, Denis Ayache, Mary Daval, Vito Pontillo   +3 more
core   +1 more source

Enhanced Recovery After Surgery Protocol in Transoral Robotic Surgery: A Case–Control Study

Clinical Otolaryngology, EarlyView.
ABSTRACT Introduction ‘Enhanced Recovery After Surgery’ (ERAS) protocols have been developed for multiple surgical procedures with favourable outcome measures including Length of Stay (LoS). Trans‐Oral Robotic Surgery (TORS) has similarly facilitated earlier patient discharges, particularly in comparison to open head and neck surgical techniques. There
Jonathan Daniel, Raguwinder Bindy Sahota, Mark David Wilkie, Lee Pryor, Ahmed Bassiouni, Jake Jervis‐Bardy, Arun Takhar, Bora Jeong, Oladejo Olaleye, Suren Krishnan, J. C. Hodge, Andrew Foreman   +11 more
wiley   +1 more source

Effectiveness of tranexamic acid in burn patients undergoing surgery – a systematic review and meta-analysis

BMC Anesthesiology
Summary Background Reducing blood loss during excisional surgery in burn patients remains a challenge. Tranexamic acid during surgery can potentially reduce blood loss.
Joeri Slob, Rolf K. Gigengack, Margriet E. van Baar, Stephan A. Loer, Seppe S. H. A. Koopman, Cornelis H. van der Vlies   +5 more
doaj   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery

Perioperative Medicine
Introduction Tranexamic acid has been widely used in plastic surgery. However, its efficacy has yet to be fully established. This meta-analysis aimed to determine its effectiveness in aesthetic plastic surgery.
Jerzy Kolasiński, Tomasz Reysner, Małgorzata Kolenda, Szymon Kołacz, Małgorzata Domagalska   +4 more
doaj   +1 more source

Effect of oral tranexamic acid on macular edema associated with retinal vein occlusion or diabetes

, 2017
Masayuki Takeyama,1 Fumio Takeuchi,2 Masahiko Gosho,3 Keijiro Sugita,1 Masahiro Zako,4 Masayoshi Iwaki,5 Motohiro Kamei1 1Department of Ophthalmology, Aichi Medical University, Nagakute, 2Department of Biochemistry, Aichi Medical University, Nagakute ...
Kamei M, Takeyama Masayuki, Zako M, GOSHO Masahiko, Sugita K, Zako Masahiro, Takeyama M, Sugita Keijiro, Iwaki Masayoshi, Gosho M, Takeuchi Fumio, Kamei Motohiro, Takeuchi F, Iwaki M   +13 more
core   +1 more source