Results 91 to 100 of about 3,929,670 (363)

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Alternative splicing of activator CcbHLH1 gene accounts for anthocyanin absence in white cornflower

Ornamental Plant Research
Anthocyanins play crucial roles in conferring multicolored characteristics to higher plant organs. Previous studies have investigated the absence of anthocyanin accumulation in white cornflower petals, where the anthocyanin biosynthesis pathway was ...
Chengyan Deng, Xiaofan Zheng, Jiaying Wang, Yanfei Li, Jingjing Li, Min Lu, Ruina Gao, Chenyuan Ji, Qinghe Hao, Silan Dai   +9 more
doaj   +1 more source

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

Retrovirology, 2009
The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in infected patients under HAART since interruption of the treatment inevitably leads to a rebound of plasma viremia.
Van Lint Carine, Colin Laurence
doaj   +1 more source

Targeting enteroviral 2A protease by a 16-mer synthetic peptide: Inhibition of 2Apro-induced apoptosis in a stable Tet-on HeLa cell line [PDF]

, 2010
Enteroviridae such as coxsackievirus are important infectious agents causing viral heart diseases. Viral protease 2A (2Apro) initiates the virus life cycle, and is an excellent target for developing antiviral drugs.
Esfandiarei, Mitra, Hadi-Alijanvand, Hamid, Khodagholi, Fariba, Maghsoudi, Amir Hossein, Maghsoudi, Nader, Moosavi, Maryam, Sabbaghian, Marjan, Sajadi, Mahnaz, Tafreshi, Narges Kh., Zakeri, Zahra, Zeinoddini, Mehdi, Zohri, Mastaneh   +11 more
core   +1 more source

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

Genes & Development, 1995
The insulin gene is one of the best paradigms of tissue-specific gene expression. It is developmentally regulated and is expressed exclusively in the pancreatic beta-cell.
F. Naya, C. M. Stellrecht, M. Tsai
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

A Role for Soluble IL-6 Receptor in Osteoarthritis

Journal of Functional Morphology and Kinesiology, 2017
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA).
Graham Akeson, Charles J. Malemud
doaj   +1 more source

System Perspective Analysis for Molecular and Genetic Source of Salt Tolerance in Cotton [PDF]

, 2020
Sources of tolerance salinity stress in plants are the results of sets of the simple effect and interaction among genes. A systematic perspective at the polygenic trait process of resistance to environmental stresses, including salinity stress, and the
Alizada, Shadar, Guliev, Rauf, Mammadova, Ruhangiz, Zaefizadeh, Mohammad   +3 more
core  

Trans activation by the bovine papillomavirus E2 protein in Saccharomyces cerevisiae [PDF]

Journal of Virology, 1989
The papillomavirus E2 protein functions as an enhancer-binding factor to promote transcription in mammalian cells. We found that one copy of the E2 binding site acted as an E2 protein-dependent upstream activating sequence in Saccharomyces cerevisiae. Additional copies of the binding motif further augmented transcription.
Elliot J. Androphy, James G. Barsoum, L. C. Morrissey   +2 more
openaire   +3 more sources