Results 151 to 160 of about 807,180 (300)

Molecular engineering of CRISPR/Cas12a: from activity enhancement to exponential signal amplification. [PDF]

Chem Sci
Li QN, Yang QF, Jin WL, Pang XZ, Sun WB, Wang JX, Wang XY, Tang AN, Kong DM, Zhu LN.   +9 more
europepmc   +1 more source

Pratiche di resistenza per l’autodeterminazione di corpi e soggettività trans/migranti

, 2020
Fau Rosati
core  

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Steric regulation of CRISPR/Cas12a trans-cleavage kinetics via split-activator extensions. [PDF]

Nucleic Acids Res
Zhang J, He X, Huang J, Cheng C, He G, Xia R, Yang J, Chen J, Guo L, Xiang D, Li F, Shi J, Li P.   +12 more
europepmc   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Structural insights into HRI kinase activity and inhibition. [PDF]

Biochem Soc Trans
Cao M, Masson GR.
europepmc   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Lead Optimization: Synthesis and Biological Evaluation of Griseofulvin Derivatives as Novel SIRT6 Activators. [PDF]

ACS Med Chem Lett
Zorko T, Kogovšek J, Ciber L, Ostojić I, Maraš N, Novinec M, Štefane B.   +6 more
europepmc   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation. [PDF]

NPJ Syst Biol Appl
Li D, Morita K, Kokaji T, Hatano A, Hirayama A, Soga T, Suzuki Y, Matsumoto M, Tsuchiya T, Ozaki H, Ohno S, Inoue H, Inaba Y, Maehara H, Sugimoto H, Pan Y, Kuroda S.   +16 more
europepmc   +1 more source