Results 181 to 190 of about 807,180 (300)

Pharmacological Investigation of a Novel Resveratrol-like SIRT1 Activator Endowed with a Cardioprotective Profile. [PDF]

Molecules
Carbonetti L, Brogi S, D'Orsi R, Lessi M, Calderone V, Testai L, Bellina F.   +6 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis. [PDF]

Crit Care Explor
Inman K, Chernus J, Lee M, Alder JK, Shah FA, Mayr FB, Dempsey T, Nouraie SM, Dela Cruz C, Ferreira VP, Kulkarni HS, Meyer NJ, Strollo PJ, Feingold E, Bain W.   +14 more
europepmc   +1 more source

Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials

Advanced Science, EarlyView.
Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan, Hengheng Zhao, Haotian Wang, Zhanjie Liu, Qian Li, Weifeng Zhang, Qingsong Zhao, Liqun Zhang, Jun Liu   +8 more
wiley   +1 more source

Cooperative Split DNA Activation of CRISPR-Cas12a for Sensitive and Selective Detection of Flunixin. [PDF]

ACS Meas Sci Au
Chen J, Munusamy S, Jahani R, Guan R, Zheng H, Zhou S, Kong J, Zhao Y, Guan L, Kanaherarachchi A, Guan X.   +10 more
europepmc   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

The Semantics and Mechanisms of Enhancers and Promoters: "What Is True for <i>E. coli</i> Is True for the Elephant, Only More So". [PDF]

Annu Rev Biochem
Struhl K.
europepmc   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Port Authority Trans-Hudson (PATH) Minutes

, 2007
Port Authority Trans-Hudson Corporation
core   +2 more sources

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus. [PDF]

Nat Struct Mol Biol
Schwämmle T, Noviello G, Kanata E, Froehlich JJ, Bothe M, Martitz A, Altay A, Scouarnec J, Feng VY, Mallie H, Vingron M, Schulz EG.   +11 more
europepmc   +1 more source