Results 241 to 250 of about 3,929,670 (363)

Characterization of a potent varicella-zoster virus-encoded trans-repressor

Journal of Virology, 1991
Sunil Nagpal, J. Ostrove
semanticscholar   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator. [PDF]

J Pharmacol Exp Ther
Weigele J, Zhang L, Franco A, Cartier E, Dorn GW.   +4 more
europepmc   +1 more source

Trans-activation of the mouse cytomegalovirus immediate early gene enhancer by ras oncogenes

, 1994
David Lembo, A Angeretti, Paola Foresta, Giorgio Gribaudo, Marisa Gariglio, Santo Landolfo   +5 more
openalex   +1 more source

The DMB promoter: delineation, in vivo footprint, trans-activation, and trans-dominant suppression. [PDF]

, 1997
Jenny P.‐Y. Ting, Kenneth L. Wright, Keh Chuang Chin, W. June Brickey, G Li   +4 more
openalex   +1 more source

Transient gene expression control: effects of transfected DNA stability and trans-activation by viral early proteins

Molecular and Cellular Biology, 1985
J. Alwine
semanticscholar   +1 more source

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

Split crRNA with CRISPR-Cas12a enabling highly sensitive and multiplexed detection of RNA and DNA. [PDF]

Nat Commun
Chen Y, Wang X, Zhang J, Jiang Q, Qiao B, He B, Yin W, Qiao J, Liu Y.   +8 more
europepmc   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation. [PDF]

Immunometabolism (Cobham)
Spector L, Subramanian N.
europepmc   +1 more source